NIH VideoCast - Chemokine Receptors in the Differentiation of Human CD4+ Effector/Memory T Cells

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Chemokine Receptors in the Differentiation of Human CD4+ Effector/Memory T Cells

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Air date:	Wednesday, June 18, 2008, 4:15:00 PM Time displayed is Eastern Time, Washington DC Local
Views:	Total views: 148 * This only includes stats from October 2011 and forward.
Category:	Immunology
Runtime:	00:59:28
Closed captioning:	Check box to display CC outside of the video Note: You can drag the captioning window around and resize it
Description:	Josh Farber's research has focused on lymphocyte-active chemokines and their receptors. In early work, his laboratory discovered the major Th1 chemokine CXCL9 (Mig) and several critical T cell chemokine receptors, including CCR6, CXCR6, and CCR9A/B. In 1997, in collaboration with Ed Berger and Keith Peden, he showed that CXCR6 is a coreceptor for SIV and certain strains of HIV. In more recent work he has been investigating chemokine receptor signaling and the epigenetics of chemokine receptor expression on human lymphocytes, and using chemokine receptor patterns to study the differentiation of human CD4+ effector/memory T cells. The latter studies have revealed that CCR5 and CCR2 identify subsets of potentially long-lived, highly differentiated effector memory T cells, so-called first responders, and that CCR6 is the chemokine receptor found on all Th17 cells. Currently, his laboratory is investigating the importance of CCR6 in models of Th17-mediated disease. Come hear about these and other exciting findings from one of NIH's own. For more information, visit The Immunology Interest Group

NLM Title:	Chemokine receptors in the differentiation of human CD4+ effector/memory T cells / Joshua Farber ; Immunology Interest Group.
Author:	Farber, Joshua. National Institutes of Health (U.S.). Immunology Interest Group.
Publisher:
Abstract:	(CIT): Josh Farber's research has focused on lymphocyte-active chemokines and their receptors. In early work, his laboratory discovered the major Th1 chemokine CXCL9 (Mig) and several critical T cell chemokine receptors, including CCR6, CXCR6, and CCR9A/B. In 1997, in collaboration with Ed Berger and Keith Peden, he showed that CXCR6 is a coreceptor for SIV and certain strains of HIV. In more recent work he has been investigating chemokine receptor signaling and the epigenetics of chemokine receptor expression on human lymphocytes, and using chemokine receptor patterns to study the differentiation of human CD4+ effector/memory T cells. The latter studies have revealed that CCR5 and CCR2 identify subsets of potentially long-lived, highly differentiated effector memory T cells, so-called first responders, and that CCR6 is the chemokine receptor found on all Th17 cells. Currently, his laboratory is investigating the importance of CCR6 in models of Th17-mediated disease. Come hear about these and other exciting findings from one of NIH's own.
Subjects:	CD4-Positive T-Lymphocytes--immunology Receptors, Chemokine--immunology
Publication Types:	Lecture Webcast
NLM Classification:	QW 568
NLM ID:	101478258
CIT Live ID:	6739
Permanent link:	https://videocast.nih.gov/watch=6739

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