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Systems Biology: Network of Networks
Wednesday, April 2, 2008,
3:00:00 PM Time displayed is Eastern Time, Washington DC Local
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At a molecular level biological systems such as cell signaling or metabolism can be represented as dynamic networks of interacting molecules and a key objective of systems biology is to investigate the structure and dynamic behavior of such networks. In the living cell multiple types of networks are concurrently present and active. These include gene regulatory
(transcriptional) networks, protein:protein interaction networks, networks of enzymes and their substrates (e.g. protein kinase-substrate networks), networks of microRNA’s and their substrates etc. Notably, most of these types of networks consist of or involve proteins. Therefore, the systematic analysis or the proteins that constitute a biological system and the networks they constitute is a central theme of the emerging field of systems biology.
Mass spectrometry is the most widely used method for the analysis of proteins and proteomes. In this presentation we will discuss new mass spectrometry based technologies for the analysis of different types of cellular networks and their dynamic change as a function of cellular state. These include protein:protein interaction networks, networks of concurrently regulated proteins and networks of protein kinases and their substrates. Selected applications will illustrate the current status of these new technologies.
Dr. Aebersold completed his undergraduate studies in biology at the University of Basel, Switzerland in 1979 and received a Ph.D. in cell biology at the Biocenter of the University of Basel in 1984. Holding fellowships from the Swiss National Science Foundation and EMBO, he joined the California Institute of Technology as a postdoctoral fellow (1984-86) and remained at Caltech as a senior research fellow (1986-88). In 1988, he joined the University of British Columbia in Vancouver as an assistant professor in the Department of Biochemistry and Molecular Biology and as a senior investigator at the Biomedical Research Centre. In 1993, he moved to the University of Washington as an Associate Professor in Molecular Biotechnology and was promoted to full Professor in 1998. He served as the Associate Director for the Science and Technology Center for Molecular Biotechnology from
1994-2000. In 2000, he left the University of Washington and joined the
Institute for Systems Biology as co-founder and full faculty member. In November 2004, he assumed an appointment as Professor of Systems Biology, Institute of Molecular Systems Biology, ETH-Zürich and at Faculty of Sciences, University of Zürich.
Dr. Aebersold’s research focuses on developing new methods and technologies for quantitative proteomics and for applying this emerging technology to enhance our understanding of the structure, function, and control of complex biological systems. Current applications of quantitative proteomics technology are directed towards the discovery of proteins markers that differentiate cancer cells from their normal counterparts, to the investigation of the mechanisms of fundamental cellular processes by the comparative analysis of the gene and protein expression profiles in cells at different states.