NIH VideoCast - Genome-wide Discovery of Post-translational Modulators of Transcriptional Interactions in Human B Lymphocytes

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Genome-wide Discovery of Post-translational Modulators of Transcriptional Interactions in Human B Lymphocytes

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Air date:	Tuesday, February 20, 2007, 1:00:00 PM Time displayed is Eastern Time, Washington DC Local
Views:	Total views: 97 * This only includes stats from October 2011 and forward.
Category:	Special
Runtime:	01:00:40
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Description:	Transcriptional interactions in the cell are modulated by a variety of mechanisms that prevent their representation as pairwise interactions between a transcription factor and its targets. These include, among others, transcription factor modification by phosphorylation and acetylation, formation of active complexes with one or more transcriptional co-factors, and protein specific degradation and stabilization processes. We introduce a method for the genome-wide computational inference of post-translational modulators of a transcription factor, which are able to affect the ability of the TF to activate/repress its targets. This information theoretic method, MINDY, directly analyzes the multivariate statistical dependencies between a transcription factor and one or more of its targets, conditional on the presence (or absence) of a candidate modulator gene. For more information, visit http://www.nih.gov/sigs/sysbio

NLM Title:	Genome-wide discovery of post-translational modulators of transcriptional interactions in human B lymphocytes / Andrea Califano.
Author:	Califano, Andrea. National Institutes of Health (U.S.)
Publisher:
Abstract:	(CIT): Transcriptional interactions in the cell are modulated by a variety of mechanisms that prevent their representation as pairwise interactions between a transcription factor and its targets. These include, among others, transcription factor modification by phosphorylation and acetylation, formation of active complexes with one or more transcriptional co-factors, and protein specific degradation and stabilization processes. We introduce a method for the genome-wide computational inference of post-translational modulators of a transcription factor, which are able to affect the ability of the TF to activate/repress its targets. This information theoretic method, MINDY, directly analyzes the multivariate statistical dependencies between a transcription factor and one or more of its targets, conditional on the presence (or absence) of a candidate modulator gene. For more information, visit http://www.nih.gov/sigs/sysbio.
Subjects:	B-Lymphocytes Protein Processing, Post-Translational. Transcription Factors--metabolism
Publication Types:	Lecture Webcast
NLM Classification:	QU 475
NLM ID:	101300944
CIT Live ID:	5733
Permanent link:	https://videocast.nih.gov/watch=5733

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