NIH VideoCast - NIH Director's Seminar Series - The Paraventricular Thalamus: An Integrative Node Underlying Homeostatic Behavior

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NIH Director's Seminar Series - The Paraventricular Thalamus: An Integrative Node Underlying Homeostatic Behavior

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Air date:	Friday, March 8, 2024, 12:00:00 PM Time displayed is Eastern Time, Washington DC Local
Views:	Total views: 119 (89 Live, 30 On-demand)
Category:	NIH Director's Seminars
Runtime:	01:02:07
Closed captioning:	Check box to display CC outside of the video Note: You can drag the captioning window around and resize it
Description:	The nervous system orchestrates adaptive behaviors by intricately coordinating responses to internal cues and environmental stimuli. This involves integrating sensory input, managing competing motivational states, and drawing on past experiences to anticipate future outcomes. While traditional models attribute this complexity to interactions between the mesocorticolimbic system and hypothalamic centers, the specific nodes of integration have remained elusive. Recent research, including our own, sheds light on the midline thalamus's overlooked role in this process. We propose that the midline thalamus integrates internal states with memory and emotional signals to guide adaptive behaviors. Our investigations into midline thalamic neuronal circuits have provided crucial insights into the neural mechanisms behind flexibility and adaptability. Understanding these processes is essential for deciphering human behavior and conditions marked by impaired motivation and emotional processing. Our research aims to contribute to this understanding, paving the way for targeted interventions and therapies to address such impairments.

NLM Title:	The paraventricular thalamus : an integrative node underlying homeostatic behavior / Mario Penzo.
Author:	Penzo, Mario. National Institutes of Health (U.S.),
Publisher:
Abstract:	(CIT): The nervous system orchestrates adaptive behaviors by intricately coordinating responses to internal cues and environmental stimuli. This involves integrating sensory input, managing competing motivational states, and drawing on past experiences to anticipate future outcomes. While traditional models attribute this complexity to interactions between the mesocorticolimbic system and hypothalamic centers, the specific nodes of integration have remained elusive. Recent research, including our own, sheds light on the midline thalamus's overlooked role in this process. We propose that the midline thalamus integrates internal states with memory and emotional signals to guide adaptive behaviors. Our investigations into midline thalamic neuronal circuits have provided crucial insights into the neural mechanisms behind flexibility and adaptability. Understanding these processes is essential for deciphering human behavior and conditions marked by impaired motivation and emotional processing. Our research aims to contribute to this understanding, paving the way for targeted interventions and therapies to address such impairments.
Subjects:	Emotions--physiology Homeostasis--physiology Midline Thalamic Nuclei--physiology Neuronal Plasticity
Publication Types:	Lecture Webcast
NLM Classification:	WL 312
NLM ID:	9918820067106676
CIT Live ID:	54415
Permanent link:	https://videocast.nih.gov/watch=54415

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