Skip Navigation

NIH ProtIG Seminar by Stefani Thomas: Development of proteogenomic ovarian cancer biomarkers: diagnostic of disease stage and predictive of therapeutic response

Loading video...

34 Views

Air date: Thursday, January 11, 2024, 1:00:00 PM
Time displayed is Eastern Time, Washington DC Local
Views: Total views: 34 (10 Live, 24 On-demand)
Category: Special
Runtime: 01:00:22
Description: Currently, no clinical test is approved by the US FDA to screen the general population for ovarian cancer – the most lethal gynecologic malignancy in women. Additionally, to improve the selection of patients with ovarian cancer who are most likely to benefit from targeted therapy, there is a critical need to adopt analytical approaches beyond conventional genomic scar assays. Ovarian cancer patients experience a broad spectrum of clinical benefit in response to targeted therapy based on their tumor mutational profile. Mass spectrometry (MS)-based proteomic and proteogenomic approaches can address these gaps in clinical care. Traditional antibody-based immunoassays to measure protein biomarkers have significant limitations such as low-multiplexing, low inter-laboratory reproducibility, and lack of antibody specificity. Targeted MS assays can overcome these limitations. Our efforts to develop and conduct analytical validation of a multiplexed, targeted MS parallel reaction monitoring (PRM) assay for the relative quantification of a panel of putative ovarian cancer protein biomarkers in serum (n=69 women) will be discussed. Our insights into the proteogenomic determinants of response to poly(ADP)-ribose polymerase inhibitors (PARPi) and histone deacetylase inhibitors (HDACi) in the context of targeted therapy for BRCA-mutated high-grade serous ovarian cancer will also be shared.
Author: Stefani Thomas
 
CIT Live ID: 54120
Permanent link: https://videocast.nih.gov/watch=54120

Related Videos...

Click Here to Play Video.
03:40:38
Biomarkers: Promise vs. Reality
[Proteomics]
9/13/2006
Click Here to Play Video.
07:14:11
NIH State-of-the-Science Conference: Family History and Improving Health - Day 1
[Conferences]
8/24/2009
Click Here to Play Video.
07:18:32
RAS Initiative Symposium (Day 2)
[NIH Only]
12/16/2015
Click Here to Play Video.
04:03:52
National Advisory Council on Aging - September 2023
[Advisory Boards and Councils]
9/20/2023
Click Here to Play Video.
04:55:09
NIH Synthetic Biology Consortium Annual Meeting (Day 2)
[Conferences]
11/3/2023
Click Here to Play Video.
06:26:55
40 Years of Cancer Epigenetics Symposium
[Special]
10/20/2023
Click Here to Play Video.
01:02:06
NIH ProtIG Seminar: The role of long-lived proteins in aging and Alzheimer’s disease
[Special]
12/14/2023
Click Here to Play Video.
07:39:48
2024 NIH Alzheimer's Research Summit: Building a Precision Medicine Research Enterprise - Day 1
[Special]
9/23/2024
Click Here to Play Video.
06:15:28
Past, Present, and Future of Cellular Immunotherapy
[Special]
9/26/2024
Click Here to Play Video.
06:27:45
61st Meeting of the NIH Advisory Committee on Research on Women's Health
[Special]
10/8/2024