Structure Determination of Amyloid and Membrane Proteins with Solid State NMR

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Air date:	Wednesday, January 24, 2007, 3:00:00 PM Time displayed is Eastern Time, Washington DC Local
Views:	Total views: 113 * This only includes stats from October 2011 and forward.
Category:	WALS - Wednesday Afternoon Lectures
Runtime:	01:05:31
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Description:	Many biological systems form nanostructures that are well ordered on a microscopic but not a macroscopic scale, and are therefore difficult to examine with standard tools of structural biology. Two examples that exhibit these properties are amyloid and membrane proteins that assemble, respectively, into fibrils and biological membranes. In this presentation we review the properties of fibrils and membrane proteins and outline approaches to determining the structure of these systems with high resolution solid state magic angle spinning (MAS) NMR techniques. The NIH Director's Wednesday Afternoon Lecture Series includes weekly scientific talks by some of the top researchers in the biomedical sciences worldwide.

NLM Title:	Structure determination of amyloid and membrane proteins with solid state NMR / Robert G. Griffin.
Author:	Griffin, Robert G. National Institutes of Health (U.S.)
Publisher:
Abstract:	(CIT): Many biological systems form nanostructures that are well ordered on a microscopic but not a macroscopic scale, and are therefore difficult to examine with standard tools of structural biology. Two examples that exhibit these properties are amyloid and membrane proteins that assemble, respectively, into fibrils and biological membranes. In this presentation we review the properties of fibrils and membrane proteins and outline approaches to determining the structure of these systems with high resolution solid state magic angle spinning (MAS) NMR techniques.
Subjects:	Amyloid beta-Peptides--chemistry Membrane Proteins--chemistry Nuclear Magnetic Resonance, Biomolecular--methods
Publication Types:	Lecture Webcast
NLM Classification:	QU 55
NLM ID:	101298627
CIT Live ID:	5185
Permanent link:	https://videocast.nih.gov/watch=5185

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