New Aspects of NFkappaB and STAT Activation and Function in Cancer and Inflammation

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Air date:	Wednesday, November 8, 2006, 3:00:00 PM Time displayed is Eastern Time, Washington DC Local
Views:	Total views: 101 * This only includes stats from October 2011 and forward.
Category:	WALS - Wednesday Afternoon Lectures
Runtime:	00:56:09
Closed captioning:	Check box to display CC outside of the video Note: You can drag the captioning window around and resize it
Description:	George Stark has contributed to several different areas of science. Early work on enzyme mechanisms and protein chemistry led to the development of the Northern and Western techniques for analysis of specific RNAs and proteins. His laboratory has also studied gene amplification in mammalian cells, leading to an appreciation both of the mechanisms that generate amplified structures and the regulatory processes that prevent amplification from occurring in normal cells. A major project was to apply systematic genetic analysis to interferon-dependent signaling pathways. In collaboration with Dr. Ian Kerr, eight different mutant cell lines were isolated, each complemented by a cDNA encoding a different protein in the pathway. The work with interferon, together with that of Dr. James Darnell, led to the discovery of the family of JAK-STAT signaling pathways, which mediate responses to many different extracellular factors. WALS

NLM Title:	New aspects of nFkappaB and STAT activation and function in cancer and inflammation / George R. Stark.
Author:	Stark, George R. National Institutes of Health (U.S.)
Publisher:
Subjects:	Inflammation--metabolism NF-kappa B Neoplasms--metabolism STAT Transcription Factors
Publication Types:	Lecture Webcast
NLM Classification:	QU 58.5
NLM ID:	101294014
CIT Live ID:	5177
Permanent link:	https://videocast.nih.gov/watch=5177

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