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Regulatory Circuitry of Embryonic Stem Cells
Wednesday, October 25, 2006,
3:00:00 PM Time displayed is Eastern Time, Washington DC Local
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The capacity of embryonic stem cells to self-renew and to give rise to virtually all somatic lineages holds much promise for human regenerative medicine. Moreover, embryonic stem cells provide a unique opportunity in which to study early development and cell fate decisions. We have begun to determine how transcription factors, chromatin regulators and signaling pathways control the gene expression programs responsible for stem cell self-renewal and pluripotency.
Using this genome-wide data, we have developed a model for the core regulatory circuitry of human embryonic stem cells.