Skip Navigation

NIH Director's Seminar Series: Molecular regulation of synaptic inhibition

Loading video...

166 Views

Air date: Friday, July 28, 2023, 12:00:00 PM
Time displayed is Eastern Time, Washington DC Local
Views: Total views: 166 (97 Live, 69 On-demand)
Category: NIH Director's Seminars
Runtime: 01:04:13
Description: The vast majority of fast inhibitory transmission in the brain is mediated by GABA acting on GABAA receptors (GABAARs), which provides inhibitory balance to excitatory drive and controls neuronal output. Dysregulations of GABAARs and inhibitory synapses have been implicated in a variety of brain disorders, such as epilepsy, anxiety and depression. Pharmacological intervention for these disorders relies on several drug classes that target GABAARs, such as benzodiazepines and neurosteroids. The goal of Lu laboratory is to understand the molecular and cellular mechanisms underlying the regulation of GABAARs and inhibitory synapses in health and disease. In this lecture, Dr. Lu will discuss the regulation of the GABAAR and its psychopharmacology by newly discovered transmembrane auxiliary subunits, and the therapeutic potential of signaling pathways at inhibitory synapses in brain disorders.
Author: Wei Lu, Ph.D., NINDS, NIH
CIT Live ID: 51064
Permanent link: https://videocast.nih.gov/watch=51064

Related Videos...

Click Here to Play Video.
00:50:50
Stress and the Synapse
[Neuroscience]
4/23/2012
Click Here to Play Video.
02:02:54
Demystifying Medicine - How is the Brain Organized and How Does it Work?
[Demystifying Medicine]
4/4/2023
Click Here to Play Video.
06:51:43
Neural Mechanisms of Conscious Awareness in Humans (Day 3)
[Conferences]
6/28/2023
Click Here to Play Video.
01:18:19
CCR Grand Rounds - 2023 AAAS Martin and Rose Wachtel Cancer Research Award and Lecture: Harnessing Microenvironmental Dependencies for Cancer Therapy – The Role of the Nervous System in Cancer Growth
[Special]
7/28/2023
Click Here to Play Video.
07:03:04
The Evolution of Mental Health Research
[Conferences]
9/13/2023
Click Here to Play Video.
04:53:32
2nd Annual NIH Investigator Meeting on Interoception Research
[Conferences]
11/11/2023
Click Here to Play Video.
01:14:02
WALS Lecture: Leveraging Genetics and Cell Signaling to Decipher Disorders of Excitability
[WALS - Wednesday Afternoon Lectures]
1/31/2024
Click Here to Play Video.
07:56:19
2024 NIH Alzheimer's Research Summit: Building a Precision Medicine Research Enterprise - Day 2
[Special]
9/24/2024
Click Here to Play Video.
00:58:11
WALS: DeWitt Stetten Jr. Lecture- Molecular Mechanisms Underlying Glycinergic Neurotransmission​
[WALS - Wednesday Afternoon Lectures]
11/20/2024
Click Here to Play Video.
01:16:25
The Sayer Vision Research Lecture and Award
[Special]
12/9/2024