NIH VideoCast - NIH Director's Seminar: Exploring the functions of skin as an immunological interface

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NIH Director's Seminar: Exploring the functions of skin as an immunological interface

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Air date:	Friday, June 23, 2023, 12:00:00 PM Time displayed is Eastern Time, Washington DC Local
Views:	Total views: 143 (103 Live, 40 On-demand)
Category:	NIH Director's Seminars
Runtime:	00:58:33
Closed captioning:	Check box to display CC outside of the video Note: You can drag the captioning window around and resize it
Description:	The skin is a vital barrier against environmental stressors such as thermal changes, sunlight, allergens, toxins, and microbes. An array of cell types including epithelia, fibroblasts, neurons, and vasculature act together to ensure its function. Immune cells have emerged as orchestrators of skin biology that collectively serve to reinforce the barrier against external threats. The composition and function of immune cells are constantly tuned by skin structures, microbial and inflammatory stimuli. In turn, skin immune cells engage in an active dialogue with the tissue to regulate the microbiota, limit microbial invasion and facilitate tissue repair. In this seminar, I will introduce the cell-cell crosstalk that mediate immunological and microbial homeostasis in the skin and how disruption of these communications lead to pathological inflammation such as atopic inflammation and inflammatory alopecia, as well as soft-tissue infection by skin pathobionts. I will also introduce our recent efforts to gain insight into the disease pathophysiology of the intractable vasculopathy, Degos disease.

NLM Title:	Exploring the functions of skin as an immunological interface / Keisuke (Chris) Nagao.
Author:	Nagao, Keisuke. National Institutes of Health (U.S.),
Publisher:
Abstract:	(CIT): The skin is a vital barrier against environmental stressors such as thermal changes, sunlight, allergens, toxins, and microbes. An array of cell types including epithelia, fibroblasts, neurons, and vasculature act together to ensure its function. Immune cells have emerged as orchestrators of skin biology that collectively serve to reinforce the barrier against external threats. The composition and function of immune cells are constantly tuned by skin structures, microbial and inflammatory stimuli. In turn, skin immune cells engage in an active dialogue with the tissue to regulate the microbiota, limit microbial invasion and facilitate tissue repair. In this seminar, I will introduce the cell-cell crosstalk that mediate immunological and microbial homeostasis in the skin and how disruption of these communications lead to pathological inflammation such as atopic inflammation and inflammatory alopecia, as well as soft-tissue infection by skin pathobionts. I will also introduce our recent efforts to gain insight into the disease pathophysiology of the intractable vasculopathy, Degos disease.
Subjects:	Immunologic Techniques Models, Immunological Skin--immunology
Publication Types:	Lecture Webcast
NLM Classification:	WR 100
NLM ID:	9918663184306676
CIT Live ID:	49954
Permanent link:	https://videocast.nih.gov/watch=49954

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