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IIG Seminar - Heterologous Immunity: How Infection History affects Inflammatory DiseasesHHS Only

Air date: Wednesday, June 14, 2023, 4:00:00 PM
Time displayed is Eastern Time, Washington DC Local
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Description: Our understanding of host-pathogen interaction is primarily derived from studying how the immune system protects us from a single pathogen. In contrast, it is largely unknown how this response alters the body’s ability to respond to a second infectious agent or the susceptibility to autoimmunity or cancer. Nicole Joller and her group investigate the long-term effects of pathogenic challenges on future responses. Currently, they are focusing on changes in the regulatory compartment of the adaptive immune system. The Joller laboratory employs in-vivo animal models, cellular assays and genome-scale approaches to investigate infection-induced changes in the immune system, especially in the effector and regulatory T cell compartments. Specifically, they aim to: analyze how Treg function and the composition of the Treg compartment are affected by different types of infections; determine how alterations in the Treg compartment affect susceptibility to infections and autoimmunity; investigate how previous infections affect the susceptibility to an unrelated secondary challenge; and to investigate how co-inhibitory receptors affect immune control of pathogens.

For more information go to https://www.niaid.nih.gov/research/immunology-seminars
Author: Nicole Joller
Runtime: 1 hour, 15 minutes