NIH VideoCast - NIH Director's Seminar Series: Hypothalamic cell types and circuits that drive survival behaviors

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NIH Director's Seminar Series: Hypothalamic cell types and circuits that drive survival behaviors

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Air date:	Friday, December 9, 2022, 11:00:00 AM Time displayed is Eastern Time, Washington DC Local
Views:	Total views: 106 (88 Live, 18 On-demand)
Category:	NIH Director's Seminars
Runtime:	00:53:17
Closed captioning:	Check box to display CC outside of the video Note: You can drag the captioning window around and resize it
Description:	The Aponte lab studies the role of genetically-identified neurons and their projections in behaviors that are essential for survival. Their ultimate goal is to understand how neurons in distinct hypothalamic circuits encode pain and the rewarding and addictive nature of food intake. To answer these questions, they use a combination of optogenetics, chemogenetics, electrophysiology, two- and single-photon fluorescence endomicroscopy, and behavioral assays to manipulate and measure the activity of these genetically-defined neuronal subpopulations in awake behaving mice. Recently, they showed how two of the lateral hypothalamic neuronal populations identified by the expression of the calcium-binding protein parvalbumin (PVALB; LHPV) or leptin receptor (LHLEPR) modulate pain and appetitive behaviors, respectively, in mice. Their work revealed LHPV neurons as regulators of the LH glutamatergic circuitry orchestrating pain behaviors and identified LHLEPR neurons as modulators of a hypothalamic-ventral tegmental midbrain circuit involved in controlling motivation and appetitive behaviors.

NLM Title:	Hypothalamic cell types and circuits that drive survival behaviors / Yeka Aponte.
Author:	Aponte, Yeka. National Institutes of Health (U.S.),
Publisher:
Abstract:	(CIT): The Aponte lab studies the role of genetically-identified neurons and their projections in behaviors that are essential for survival. Their ultimate goal is to understand how neurons in distinct hypothalamic circuits encode pain and the rewarding and addictive nature of food intake. To answer these questions, they use a combination of optogenetics, chemogenetics, electrophysiology, two- and single-photon fluorescence endomicroscopy, and behavioral assays to manipulate and measure the activity of these genetically-defined neuronal subpopulations in awake behaving mice. Recently, they showed how two of the lateral hypothalamic neuronal populations identified by the expression of the calcium-binding protein parvalbumin (PVALB; LHPV) or leptin receptor (LHLEPR) modulate pain and appetitive behaviors, respectively, in mice. Their work revealed LHPV neurons as regulators of the LH glutamatergic circuitry orchestrating pain behaviors and identified LHLEPR neurons as modulators of a hypothalamic-ventral tegmental midbrain circuit involved in controlling motivation and appetitive behaviors.
Subjects:	Behavior, Addictive--physiopathology Feeding Behavior--physiology Hypothalamus--cytology Neurons Reward
Publication Types:	Lecture Webcast
NLM Classification:	WL 312
NLM ID:	9918573276306676
CIT Live ID:	48704
Permanent link:	https://videocast.nih.gov/watch=48704

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