Tobacco use remains the nation’s leading preventable cause of premature death. Each year, more than 440,000 Americans die from disease caused by tobacco use, accounting for one in every five deaths. Cigarette smoking alone is responsible for more than 30% of cancer deaths annually in the U.S. and smoking is also an important cause of death from heart disease, stroke, and chronic obstructive pulmonary disease. Currently, there are an estimated 44.5 million (21%) adult smokers and an estimated 3.75 million (22%) high school student smokers in the U.S. Cigarettes are the predominant form of tobacco consumed; however, other forms of tobacco, such as smokeless tobacco, cigars, and pipes, are also used. In addition to the toll in human lives, tobacco use places an enormous economic burden on society.