NIH VideoCast - Making Sense of Large-scale Neural and Behavioral Data

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Making Sense of Large-scale Neural and Behavioral Data

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Air date:	Monday, October 24, 2022, 12:00:00 PM Time displayed is Eastern Time, Washington DC Local
Views:	Total views: 234 (109 Live, 125 On-demand)
Category:	Neuroscience
Runtime:	00:59:47
Closed captioning:	Check box to display CC outside of the video Note: You can drag the captioning window around and resize it
Description:	NIH Neuroscience Series Seminar. Dr. Volpicelli-Daley discovered that exposure of neurons to seeds of amyloid fibrils composed of alpha-synuclein causes endogenous alpha-synuclein to form aggregates that morphologically and biochemically resemble those found in Parkinson's disease. The goal of the lab is to stop this pathogenic templating of alpha-synuclein to halt the progression of Parkinson’s disease. The lab also seeks to understand the neurobiologic mechanisms by which alpha-synuclein aggregates cause neuron dysfunction. We have several projects in the lab. We are determining how LRRK2, the most common genetic cause of Parkinson's disease, impacts trafficking of alpha-synuclein to the presynaptic terminals. We are also determining how genes implicated in PD increase cognitive dysfunction. The lab utilizes biochemical techniques to identify novel proteins and protein interactions involved in alpha-synuclein aggregate formation. The lab performs super-resolution microscopy to image protein localization at nanoscale resolution. We perform live cell imaging in neurons to measure calcium transients and axonal transport. We use rodent models to determine the impact of PD genes on behavior. Finally, Dr. Volpicelli-Daley is dedicated to the success of graduate and undergraduate students in the lab that have received prestigious fellowships awards, and have successful publishing records. For more information go to https://research.ninds.nih.gov/seminars-events/neuroscience-seminar-series

NLM Title:	Does pathologic ɑ-synuclein cause dementia? / Laura Volpicelli-Daley.
Author:	Volpicelli-Daley, Laura. National Institutes of Health (U.S.),
Publisher:
Abstract:	(CIT): NIH Neuroscience Series Seminar. Dr. Volpicelli-Daley discovered that exposure of neurons to seeds of amyloid fibrils composed of alpha-synuclein causes endogenous alpha-synuclein to form aggregates that morphologically and biochemically resemble those found in Parkinson"s disease. The goal of the lab is to stop this pathogenic templating of alpha-synuclein to halt the progression of Parkinson"s disease. The lab also seeks to understand the neurobiologic mechanisms by which alpha-synuclein aggregates cause neuron dysfunction. We have several projects in the lab. We are determining how LRRK2, the most common genetic cause of Parkinson"s disease, impacts trafficking of alpha-synuclein to the presynaptic terminals. We are also determining how genes implicated in PD increase cognitive dysfunction. The lab utilizes biochemical techniques to identify novel proteins and protein interactions involved in alpha-synuclein aggregate formation. The lab performs super-resolution microscopy to image protein localization at nanoscale resolution. We perform live cell imaging in neurons to measure calcium transients and axonal transport. We use rodent models to determine the impact of PD genes on behavior. Finally, Dr. Volpicelli-Daley is dedicated to the success of graduate and undergraduate students in the lab that have received prestigious fellowships awards, and have successful publishing records.
Subjects:	Lewy Bodies--drug effects Lewy Body Disease--physiopathology Parkinson Disease--physiopathology alpha-Synuclein--pharmacology
Publication Types:	Lecture Webcast

NLM Classification:	WL 359
NLM ID:	9918503078006676
CIT Live ID:	46465
Permanent link:	https://videocast.nih.gov/watch=46465

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