NIH VideoCast - Interpreting the Evolution of SARS-CoV-2

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Interpreting the Evolution of SARS-CoV-2

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Air date:	Thursday, December 1, 2022, 12:00:00 PM Time displayed is Eastern Time, Washington DC Local
Views:	Total views: 718 (438 Live, 280 On-demand)
Category:	COVID-19
Runtime:	00:59:41
Closed captioning:	Check box to display CC outside of the video Note: You can drag the captioning window around and resize it
Description:	COVID-19 SIG SARS-CoV-2 has undergone rapid antigenic evolution over the last few years. I will discuss how the patterns of SARS-CoV-2 evolution compare to other human respiratory viruses. I will also discuss how high-throughput deep mutational scanning experiments can help us interpret the ongoing evolution and get some idea of what might come next Presentation objectives: Explain the different ways that human respiratory viruses evolve in response to immune pressure. Explain how deep mutational scanning can be used to understand the effects of viral mutations. Explain how experimental data can be used to interpret and to some degree forecast viral evolution in nature. Dr. Jesse Bloom studies evolution using viruses and viral proteins as models. Specifically focusing on the fast-evolving influenza virus, Bloom aims to understand how mutations in viral genes shape the pathogen’s ability to infect and spread. He uses computational biology and real-world data to build evolutionary models and examine different scales of viral evolution, from evolution within a single host to evolution on a global scale. In doing so, Bloom addresses both fundamental and translational questions, including those with relevance to developing more effective seasonal flu vaccines. For more information go to https://www.niaid.nih.gov/research/covid-19-sig

NLM Title:	Interpreting the evolution of SARS-CoV-2 / Jesse Bloom.
Author:	Bloom, Jesse D. National Institutes of Health (U.S.). COVID-19 Scientific Interest Group,
Publisher:
Abstract:	(CIT): COVID-19 SIG SARS-CoV-2 has undergone rapid antigenic evolution over the last few years. I will discuss how the patterns of SARS-CoV-2 evolution compare to other human respiratory viruses. I will also discuss how high-throughput deep mutational scanning experiments can help us interpret the ongoing evolution and get some idea of what might come next Presentation objectives: Explain the different ways that human respiratory viruses evolve in response to immune pressure. Explain how deep mutational scanning can be used to understand the effects of viral mutations. Explain how experimental data can be used to interpret and to some degree forecast viral evolution in nature. Dr. Jesse Bloom studies evolution using viruses and viral proteins as models. Specifically focusing on the fast-evolving influenza virus, Bloom aims to understand how mutations in viral genes shape the pathogen"s ability to infect and spread. He uses computational biology and real-world data to build evolutionary models and examine different scales of viral evolution, from evolution within a single host to evolution on a global scale. In doing so, Bloom addresses both fundamental and translational questions, including those with relevance to developing more effective seasonal flu vaccines.For more information go to https://www.niaid.nih.gov/research/covid-19-sig.
Subjects:	Evolution, Molecular. Mutation SARS-CoV-2--genetics Virus Replication
Publication Types:	Lecture Webcast

NLM Classification:	QW 168.5.C8
NLM ID:	9918573278206676
CIT Live ID:	46157
Permanent link:	https://videocast.nih.gov/watch=46157

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