NIH VideoCast - Glutamate Receptor from Single Molecules to Synapses

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Glutamate Receptor from Single Molecules to Synapses

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Air date:	Monday, October 3, 2022, 12:00:00 PM Time displayed is Eastern Time, Washington DC Local
Views:	Total views: 379 (180 Live, 199 On-demand)
Category:	Neuroscience
Runtime:	00:46:46
Closed captioning:	Check box to display CC outside of the video Note: You can drag the captioning window around and resize it
Description:	NIH Neuroscience Seminar Series Communication between nerve cells serves as the basis of all brain activity, and one of the fundamental steps involved in signal transmission between the nerve cells, is the conversion of a “chemical” signal liberated at the end of one nerve cell, into an “electrical” signal at the second nerve cell. This step is mediated by a class of membrane bound proteins known as neurotransmitter receptors. Glutamate receptors belong to this family of proteins, and are the main excitatory receptors in the central nervous system. Our laboratory is interested in gaining an understanding of agonist mediated activation and desensitization of this receptor by determining the structural changes in the protein induced by agonist binding. This is achieved by using various cutting edge spectroscopic methods that allow the characterization of the dynamic state structure of the proteins at a significantly higher resolution than X-ray structures. The structural changes thus determined are correlated to the functional consequences as measured by electrophysiological measurements. These investigations provide a detailed understanding of the agonist controlled function of the glutamate receptors and hence aid in the rational design of drugs targeting this group of important proteins that are involved in diverse neuropathologies, such as epilepsy and ischemia. For more information go to https://research.ninds.nih.gov/seminars-events/neuroscience-seminar-series

NLM Title:	Glutamate receptor from single molecules to synapses / Vasanthi Jayaraman.
Author:	Jayaraman, Vasanthi. National Institutes of Health (U.S.),
Publisher:
Abstract:	(CIT): NIH Neuroscience Seminar Series Communication between nerve cells serves as the basis of all brain activity, and one of the fundamental steps involved in signal transmission between the nerve cells, is the conversion of a "chemical" signal liberated at the end of one nerve cell, into an "electrical" signal at the second nerve cell. This step is mediated by a class of membrane bound proteins known as neurotransmitter receptors. Glutamate receptors belong to this family of proteins, and are the main excitatory receptors in the central nervous system. Our laboratory is interested in gaining an understanding of agonist mediated activation and desensitization of this receptor by determining the structural changes in the protein induced by agonist binding. This is achieved by using various cutting edge spectroscopic methods that allow the characterization of the dynamic state structure of the proteins at a significantly higher resolution than X-ray structures. The structural changes thus determined are correlated to the functional consequences as measured by electrophysiological measurements. These investigations provide a detailed understanding of the agonist controlled function of the glutamate receptors and hence aid in the rational design of drugs targeting this group of important proteins that are involved in diverse neuropathologies, such as epilepsy and ischemia.
Subjects:	Glutamates--metabolism Receptors, Glutamate--physiology Signal Transduction Synapses--chemistry
Publication Types:	Lecture Webcast

NLM Classification:	WL 102.8
NLM ID:	9918503179306676
CIT Live ID:	46155
Permanent link:	https://videocast.nih.gov/watch=46155

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