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Molecular Arms Races Shape the Evolution and Function of Antiviral Proteins

Air date: Wednesday, June 21, 2023, 2:00:00 PM
Time displayed is Eastern Time, Washington DC Local
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Description: The Malik lab studies the causes and consequences of genetic conflicts that take place between different genomes (e.g., host-virus interactions, mitochondrial conflicts with nuclear genomes) or between components of the same genome (e.g., chromosomal competition at centromeric regions). We are interested in understanding these "molecular arms races" and how they drive recurrent genetic innovation, from the perspective of both evolutionary biology and human disease. Malik and his colleagues have used an evolutionary lens to dissect and discover both primate antiviral as well as viral adaptation strategies. This lecture will describe how we use evolution-guided mutagenesis approaches to dissect and enhance the function of antiviral proteins.

For more information go to https://oir.nih.gov/wals
Author: Harmit Malik, Ph.D., Fred Hutch
Runtime: 1 hour