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How Cells Make Membrane Proteins

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Air date: Wednesday, June 14, 2023, 2:00:00 PM
Time displayed is Eastern Time, Washington DC Local
Views: Total views: 559 (199 Live, 360 On-demand)
Category: WALS - Wednesday Afternoon Lectures
Runtime: 01:05:21
Description: NIH Wednesday Afternoon Lecture

Our genomes encode ~5000 integral membrane proteins. These proteins are essential for sensing the environment, communication with other cells, transport of nutrients and metabolites, neurotransmission, and countless other physiologic processes. Newly made membrane proteins are first inserted into the endoplasmic reticulum membrane. The majority of these membrane proteins have to be weaved back and forth multiple times across the lipid bilayer, folded into a functional three-dimensional structure, and sometimes assembled with other subunits. Our research aims to understand how such complex membrane proteins are made correctly. We have taken a biochemical approach to identify and mechanistically dissect the factors involved in membrane protein targeting, insertion, folding, and assembly. We recently discovered an intramembrane chaperone that aids membrane protein folding. By studying how this chaperone functions, we revealed a new conceptual framework for membrane protein biogenesis. Ongoing efforts are aimed at understanding how multi-subunit complexes are assembled.

For more information go to https://oir.nih.gov/wals
Author: Manu Hegde, Ph.D., MRC Lab
 
CIT Live ID: 46093
Permanent link: https://videocast.nih.gov/watch=46093

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