NIH VideoCast - Inflammasomes at the Crossroads of Basic Science and Therapeutic Intervention

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Inflammasomes at the Crossroads of Basic Science and Therapeutic Intervention

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Air date:	Wednesday, March 15, 2023, 2:00:00 PM Time displayed is Eastern Time, Washington DC Local
Views:	Total views: 489 (261 Live, 228 On-demand)
Category:	WALS - Wednesday Afternoon Lectures
Runtime:	01:08:21
Closed captioning:	Check box to display CC outside of the video Note: You can drag the captioning window around and resize it
Description:	NIH Director’s Wednesday Afternoon Lecture Series Hao Wu, Ph.D., is Asa and Patricia Springer Professor of Structural Biology and Professor of Biological Chemistry and Molecular Pharmacology at Harvard Medical School. Lecture summary: "Inflammasomes are supramolecular complexes that activate inflammatory caspases (1/4/5/11), which in turn cleavage a pore forming protein GSDMD to induces pyroptosis, a lytic cell death involving spillage of cellular contents, and to mediate secretion of IL-1 family cytokines. In this talk, I will focus on 1) the assembly and trafficking of inflammasomes required for their activation, and 2) assembly and selectivity of the GSDMD pore, with substantial unpublished data." For more information go to https://oir.nih.gov/wals

NLM Title:	Inflammasomes at the crossroads of basic science and therapeutic intervention / Hao Wu.
Author:	Wu, Hao. National Institutes of Health (U.S.),
Publisher:
Abstract:	(CIT): NIH Director's Wednesday Afternoon Lecture Series Hao Wu, Ph.D., is Asa and Patricia Springer Professor of Structural Biology and Professor of Biological Chemistry and Molecular Pharmacology at Harvard Medical School. Lecture summary: "Inflammasomes are supramolecular complexes that activate inflammatory caspases (1/4/5/11), which in turn cleavage a pore forming protein GSDMD to induces pyroptosis, a lytic cell death involving spillage of cellular contents, and to mediate secretion of IL-1 family cytokines. In this talk, I will focus on 1) the assembly and trafficking of inflammasomes required for their activation, and 2) assembly and selectivity of the GSDMD pore, with substantial unpublished data." For more information go to https://oir.nih.gov/wals.
Subjects:	Caspase 1--metabolism Immunity, Innate--immunology Inflammasomes--physiology NLR Family, Pyrin Domain-Containing 3 Protein--metabolism
Publication Types:	Lecture Webcast

NLM Classification:	QU 55
NLM ID:	9918592674206676
CIT Live ID:	45974
Permanent link:	https://videocast.nih.gov/watch=45974

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