NIH VideoCast - Controlling the Message: Viral Manipulation of the Gene Expression Landscape

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Controlling the Message: Viral Manipulation of the Gene Expression Landscape

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Air date:	Wednesday, March 29, 2023, 2:00:00 PM Time displayed is Eastern Time, Washington DC Local
Views:	Total views: 448 (199 Live, 249 On-demand)
Category:	WALS - Wednesday Afternoon Lectures
Runtime:	01:02:08
Closed captioning:	Check box to display CC outside of the video Note: You can drag the captioning window around and resize it
Description:	This is the Annual WALS George Khoury Lecture. Speaker Britt Glaunsinger, Ph.D., is a professor in the Department of Molecular & Cell Biology and in Plant and Microbial Biology at University of California, Berkeley. Lecture summary: Oncogenic herpesviruses such as Kaposi’s sarcoma-associated herpesvirus restrict cellular gene expression to dampen immune responses, while simultaneously stealing the cell’s machinery to express viral genes. This restriction initiates through accelerated mRNA decay in the cytoplasm, which subsequently induces broad repression of cellular mRNA synthesis both via relocalization of RNA binding proteins and turnover of RNA polymerase subunits. Herpesviruses, which are among the most successful human pathogens, have evolved to escape this repression and maintain robust viral transcription. Late in infection, the virus assembles a unique virus-host hybrid transcription complex that connects viral gene expression to viral DNA replication and genome packaging. By studying how herpesviruses interface with these gene expression pathways, we hope to uncover conserved stress responses and new connections between seemingly distal components of the gene expression cascade. For more information go to https://oir.nih.gov/wals

NLM Title:	Controlling the message : viral manipulation of the gene expression landscape / Britt Glaunsinger.
Author:	Glaunsinger, Britt. National Institutes of Health (U.S.),
Publisher:
Abstract:	(CIT): This is the Annual WALS George Khoury Lecture. Speaker Britt Glaunsinger, Ph.D., is a professor in the Department of Molecular & Cell Biology and in Plant and Microbial Biology at University of California, Berkeley. Lecture summary: Oncogenic herpesviruses such as Kaposi"s sarcoma-associated herpesvirus restrict cellular gene expression to dampen immune responses, while simultaneously stealing the cell"s machinery to express viral genes. This restriction initiates through accelerated mRNA decay in the cytoplasm, which subsequently induces broad repression of cellular mRNA synthesis both via relocalization of RNA binding proteins and turnover of RNA polymerase subunits. Herpesviruses, which are among the most successful human pathogens, have evolved to escape this repression and maintain robust viral transcription. Late in infection, the virus assembles a unique virus-host hybrid transcription complex that connects viral gene expression to viral DNA replication and genome packaging. By studying how herpesviruses interface with these gene expression pathways, we hope to uncover conserved stress responses and new connections between seemingly distal components of the gene expression cascade.For more information go to https://oir.nih.gov/wals.
Subjects:	Gene Expression Regulation, Viral
Publication Types:	Lecture Webcast

NLM Classification:	QW 160.5
NLM ID:	9918592679106676
CIT Live ID:	45970
Permanent link:	https://videocast.nih.gov/watch=45970

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