NIH VideoCast - Antivirals for Coronaviruses: Mechanism, Resistance, and Regulation

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Antivirals for Coronaviruses: Mechanism, Resistance, and Regulation

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Air date:	Thursday, February 17, 2022, 12:00:00 PM Time displayed is Eastern Time, Washington DC Local
Views:	Total views: 627 (416 Live, 211 On-demand)
Category:	COVID-19
Runtime:	01:04:44
Closed captioning:	Check box to display CC outside of the video Note: You can drag the captioning window around and resize it
Description:	COVID-19 Scientific Interest Group lecture series Dr. Denison is a professor of pediatrics, a professor of pathology, microbiology and immunology, and the Edward Claiborne Stahlman Chair in Pediatric Physiology and Cell Metabolism at Vanderbilt University Medical Center. For more than 30 years, the Denison Lab has investigated coronavirus replication, pathogenesis and evolution, including SARS-CoV, MERS-CoV, and SARS-CoV-2. Denison and his colleagues have identified multiple critical and unique viral enzymes as novel targets for antivirals and virus attenuation. They have focused on antiviral development since 2013, directing preclinical testing for anti-CoV antivirals such as Remdesivir and Molnupiravir. SARS-CoV-2 has demonstrated remarkable adaptation over the course of the pandemic, particularly with the potential for escape from countermeasures aimed at virus neutralization, thus highlighting an ongoing need to define direct acting antivirals targeting virus replication. The coronaviruses express a large replicase polyprotein from the input genome RNA, containing 16 nonstructural proteins (nsp1-16) that include two proteases, polymerase, helicase, capping functions, RNA binding proteins, and the novel nsp14 RNA proofreading function, and which together assemble into a multi-protein replicase complex. The seminar will summarize the remarkable biology of the CoV replicase, highlight the targets and mechanisms of EUA / approved antivirals, and define paths forward to prevent resistance and enhance activity against SARS-CoV-2. For more information go to https://www.niaid.nih.gov/research/covid-19-sig

NLM Title:	Antivirals for coronaviruses : mechanism, resistance, and regulation / Mark R. Denison.
Author:	Denison, Mark. National Institutes of Health (U.S.). COVID-19 Scientific Interest Group,
Publisher:
Abstract:	(CIT): Dr. Denison is a professor of pediatrics, a professor of pathology, microbiology and immunology, and the Edward Claiborne Stahlman Chair in Pediatric Physiology and Cell Metabolism at Vanderbilt University Medical Center. For more than 30 years, the Denison Lab has investigated coronavirus replication, pathogenesis and evolution, including SARS-CoV, MERS-CoV, and SARS-CoV-2. Denison and his colleagues have identified multiple critical and unique viral enzymes as novel targets for antivirals and virus attenuation. They have focused on antiviral development since 2013, directing preclinical testing for anti-CoV antivirals such as Remdesivir and Molnupiravir. SARS-CoV-2 has demonstrated remarkable adaptation over the course of the pandemic, particularly with the potential for escape from countermeasures aimed at virus neutralization, thus highlighting an ongoing need to define direct acting antivirals targeting virus replication. The coronaviruses express a large replicase polyprotein from the input genome RNA, containing 16 nonstructural proteins (nsp1-16) that include two proteases, polymerase, helicase, capping functions, RNA binding proteins, and the novel nsp14 RNA proofreading function, and which together assemble into a multi-protein replicase complex. The seminar will summarize the remarkable biology of the CoV replicase, highlight the targets and mechanisms of EUA / approved antivirals, and define paths forward to prevent resistance and enhance activity against SARS-CoV-2.
Subjects:	Antiviral Agents COVID-19 Vaccines COVID-19--drug therapy COVID-19--prevention & control Drug Resistance, Viral SARS-CoV-2--drug effects.
Publication Types:	Lecture Webcast

NLM Classification:	W 506.6
NLM ID:	9918367464606676
CIT Live ID:	44539
Permanent link:	https://videocast.nih.gov/watch=44539

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