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Marathons for T Cells: How They Keep on Killing
Wednesday, June 15, 2022,
3:00:00 PM Time displayed is Eastern Time, Washington DC Local
This WALS talk is jointly sponsored with the IIG. Dr. Griffiths is a Wellcome Trust Principal Research Fellow and a professor of immunology and cell biology at Cambridge Institute for Medical Research. For this lecture, Dr. Griffiths will focus on the cell biology that underlies the remarkable ability of cytotoxic T lymphocytes to act as serial killers, with individual cells providing sustained killing in response to cancer or virally infected targets. She will describe a screen that picked up genes that are required for sustained killing and revealed an unexpected role for mitochondria as homestatic regulators of CTL killing. She then will describe work by a former NIH-OxCam student that reveals an (again unexpected) role for transcription during killing.