NIH VideoCast - Neuronal Response to Injury and Stress: Insights from C. elegans

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Neuronal Response to Injury and Stress: Insights from C. elegans

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Air date:	Tuesday, June 7, 2022, 3:00:00 PM Time displayed is Eastern Time, Washington DC Local
Views:	Total views: 296 (147 Live, 149 On-demand)
Category:	WALS - Wednesday Afternoon Lectures
Runtime:	01:04:42
Closed captioning:	Check box to display CC outside of the video Note: You can drag the captioning window around and resize it
Description:	NIH Director’s Wednesday Afternoon Lecture Series Yishi Jin is interested in identifying the molecular mechanisms controlling synapse formation and axon guidance in the nematode Caenorhabditis elegans. Neurons employ many mechanisms to sustain function throughout lifetime. Following traumatic injury to axons, neurons often initiate complex responses to regenerate and repair. To understand the underlying mechanisms, we established in vivo laser axotomy assay in C. elegans. Using live imaging, we characterized rapid cellular dynamics following axon injury. We carried out large-scale genetic screening and discovered several molecular pathways. This talk aims to give an overview of the conserved mechanisms, focusing on our studies of axonal protein phase separation and the regulation of a stress-sensing kinase. For more information go to https://oir.nih.gov/wals

NLM Title:	Neuronal response to injury and stress : insights from C. elegans / Yishi Jin.
Author:	Jin, Yishi. National Institutes of Health (U.S.),
Publisher:
Abstract:	(CIT): NIH Director's Wednesday Afternoon Lecture Series Yishi Jin is interested in identifying the molecular mechanisms controlling synapse formation and axon guidance in the nematode Caenorhabditis elegans. Neurons employ many mechanisms to sustain function throughout lifetime. Following traumatic injury to axons, neurons often initiate complex responses to regenerate and repair. To understand the underlying mechanisms, we established in vivo laser axotomy assay in C. elegans. Using live imaging, we characterized rapid cellular dynamics following axon injury. We carried out large-scale genetic screening and discovered several molecular pathways. This talk aims to give an overview of the conserved mechanisms, focusing on our studies of axonal protein phase separation and the regulation of a stress-sensing kinase.
Subjects:	Axons--physiology Caenorhabditis elegans Microtubules--physiology Nerve Regeneration--physiology Peripheral Nerve Injuries--physiopathology Stress, Physiological
Publication Types:	Lecture Webcast

NLM Classification:	WL 530
NLM ID:	9918434186106676
CIT Live ID:	44261
Permanent link:	https://videocast.nih.gov/watch=44261

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