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Yishi Jin is interested in identifying the molecular mechanisms controlling synapse formation and axon guidance in the nematode Caenorhabditis elegans. Neurons employ many mechanisms to sustain function throughout lifetime. Following traumatic injury to axons, neurons often initiate complex responses to regenerate and repair. To understand the underlying mechanisms, we established in vivo laser axotomy assay in C. elegans. Using live imaging, we characterized rapid cellular dynamics following axon injury. We carried out large-scale genetic screening and discovered several molecular pathways. This talk aims to give an overview of the conserved mechanisms, focusing on our studies of axonal protein phase separation and the regulation of a stress-sensing kinase.\n

For more information go to https://oir.nih.gov/wals"}],["$","meta","2",{"name":"publisher","content":"National Institutes of Health"}],["$","meta","3",{"property":"og:title","content":"NIH VideoCast - Neuronal Response to Injury and Stress: Insights from C. elegans"}],["$","meta","4",{"property":"og:description","content":"NIH Director’s Wednesday Afternoon Lecture Series

Yishi Jin is interested in identifying the molecular mechanisms controlling synapse formation and axon guidance in the nematode Caenorhabditis elegans. Neurons employ many mechanisms to sustain function throughout lifetime. Following traumatic injury to axons, neurons often initiate complex responses to regenerate and repair. To understand the underlying mechanisms, we established in vivo laser axotomy assay in C. elegans. Using live imaging, we characterized rapid cellular dynamics following axon injury. We carried out large-scale genetic screening and discovered several molecular pathways. This talk aims to give an overview of the conserved mechanisms, focusing on our studies of axonal protein phase separation and the regulation of a stress-sensing kinase.\n

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Yishi Jin is interested in identifying the molecular mechanisms controlling synapse formation and axon guidance in the nematode Caenorhabditis elegans. Neurons employ many mechanisms to sustain function throughout lifetime. Following traumatic injury to axons, neurons often initiate complex responses to regenerate and repair. To understand the underlying mechanisms, we established in vivo laser axotomy assay in C. elegans. Using live imaging, we characterized rapid cellular dynamics following axon injury. We carried out large-scale genetic screening and discovered several molecular pathways. This talk aims to give an overview of the conserved mechanisms, focusing on our studies of axonal protein phase separation and the regulation of a stress-sensing kinase.\n

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