NIH VideoCast - Organoids to Model Human Disease

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Organoids to Model Human Disease

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Air date:	Wednesday, April 20, 2022, 3:00:00 PM Time displayed is Eastern Time, Washington DC Local
Views:	Total views: 733 (395 Live, 338 On-demand)
Category:	WALS - Wednesday Afternoon Lectures
Runtime:	00:59:08
Closed captioning:	Check box to display CC outside of the video Note: You can drag the captioning window around and resize it
Description:	NIH Wednesday Afternoon Lecture Stem cells are the foundation of all mammalian life. They come in two flavors. Embryonic stem cells are briefly present in the early human or mouse embryo, a few days after fertilization. These stem cells can be grown indefinitely in the lab and have the potential to build each and every tissue in our body. ES cells hold great promise in the field of regenerative medicine. Adult stem cells. Every organ in our body harbors its own dedicated stem cells. These adult stem cells replace tissue that is lost due to wear and tear, trauma and disease. Adult stem cells can only produce the tissue in which they reside. The adult stem cells allow us to live 80-90 years, but this comes at a cost: they easily turn into cancer. Both types of stem cells can be used to establish ‘organoids’, 3D structures established in a dish, that recapitulate many aspects of the original organ -including its diseases. For more information go to https://oir.nih.gov/wals

NLM Title:	Organoids to model human disease / Hans Clevers.
Author:	Clevers, Hans. National Institutes of Health (U.S.),
Publisher:
Abstract:	(CIT): Stem cells are the foundation of all mammalian life. They come in two flavors. Embryonic stem cells are briefly present in the early human or mouse embryo, a few days after fertilization. These stem cells can be grown indefinitely in the lab and have the potential to build each and every tissue in our body. ES cells hold great promise in the field of regenerative medicine. Adult stem cells. Every organ in our body harbors its own dedicated stem cells. These adult stem cells replace tissue that is lost due to wear and tear, trauma and disease. Adult stem cells can only produce the tissue in which they reside. The adult stem cells allow us to live 80-90 years, but this comes at a cost: they easily turn into cancer. Both types of stem cells can be used to establish "organoids", 3D structures established in a dish, that recapitulate many aspects of the original organ -including its diseases.
Subjects:	Adult Stem Cells Embryonic Stem Cells Models, Biological Organ Culture Techniques Organoids Tissue Engineering
Publication Types:	Lecture Webcast

NLM Classification:	QS 525
NLM ID:	9918418884706676
CIT Live ID:	44246
Permanent link:	https://videocast.nih.gov/watch=44246

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