NIH VideoCast - Reconstruction of the Pathophysiology of Chronic Pain from Genome-wide Studies

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Reconstruction of the Pathophysiology of Chronic Pain from Genome-wide Studies

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Air date:	Wednesday, February 9, 2022, 3:00:00 PM Time displayed is Eastern Time, Washington DC Local
Views:	Total views: 346 (217 Live, 129 On-demand)
Category:	WALS - Wednesday Afternoon Lectures
Runtime:	01:08:44
Closed captioning:	Check box to display CC outside of the video Note: You can drag the captioning window around and resize it
Description:	Wednesday Afternoon Lecture Series Dr. Diatchenko is a Canada Excellence Research Chair in Human Pain Genetics and the Pfizer Canada Professor in Pain Research at McGill's Faculty of Dental Medicine and Oral Health Sciences in Montreal. She has developed several widely-used and widely-cited molecular tools for the analysis of gene expression and regulation. Diatchenko's most recent line of research is focused on determining the genetic mechanisms that impact and shape human pain perception and risk of development of chronic pain conditions, enabling new approaches to identify drug targets, treatment responses to analgesics, and diagnostics. The molecular pathophysiology of chronic pain is largely unknown. The genetic and molecular studies of human pain can nevertheless provide critical insights into pathophysiological mechanisms of pain "chronification," the process of transient pain progressing into persistent pain. In this talk, Dr. Diatchenko will describe three examples of how genome-wide genetic profiling, immune profiling, and transcriptome-wide profiling provide new and unexpected insights into human chronic pain molecular pathophysiology. She will discuss how these approaches identified substantial shared genetic heritability between different chronic pain conditions driven by netrin-dependent axonal guidance projection, a natural killer cell-peripheral nerve axis in fibromyalgia, and how acute inflammatory response via neutrophil activation protects against pain chronification. For more information go to https://oir.nih.gov/wals

NLM Title:	Reconstruction of the pathophysiology of chronic pain from genome-wide studies / Luda Diatchenko.
Author:	Diatchenko, Luda. National Institutes of Health (U.S.),
Publisher:
Abstract:	(CIT): Dr. Diatchenko is a Canada Excellence Research Chair in Human Pain Genetics and the Pfizer Canada Professor in Pain Research at McGill"s Faculty of Dental Medicine and Oral Health Sciences in Montreal. She has developed several widely-used and widely-cited molecular tools for the analysis of gene expression and regulation. Diatchenko"s most recent line of research is focused on determining the genetic mechanisms that impact and shape human pain perception and risk of development of chronic pain conditions, enabling new approaches to identify drug targets, treatment responses to analgesics, and diagnostics. The molecular pathophysiology of chronic pain is largely unknown. The genetic and molecular studies of human pain can nevertheless provide critical insights into pathophysiological mechanisms of pain "chronification," the process of transient pain progressing into persistent pain. In this talk, Dr. Diatchenko will describe three examples of how genome-wide genetic profiling, immune profiling, and transcriptome-wide profiling provide new and unexpected insights into human chronic pain molecular pathophysiology. She will discuss how these approaches identified substantial shared genetic heritability between different chronic pain conditions driven by netrin-dependent axonal guidance projection, a natural killer cell-peripheral nerve axis in fibromyalgia, and how acute inflammatory response via neutrophil activation protects against pain chronification.
Subjects:	Chronic Pain--genetics Chronic Pain--physiopathology Genetic Profile Genomics
Publication Types:	Lecture Webcast

NLM Classification:	WL 704
NLM ID:	9918351570906676
CIT Live ID:	44205
Permanent link:	https://videocast.nih.gov/watch=44205

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