NIH VideoCast - Cytokine Signaling: The More Things Change, the More They Stay the Same

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Cytokine Signaling: The More Things Change, the More They Stay the Same

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Air date:	Wednesday, December 15, 2021, 3:00:00 PM Time displayed is Eastern Time, Washington DC Local
Views:	Total views: 931 (534 Live, 397 On-demand)
Category:	WALS - Wednesday Afternoon Lectures
Runtime:	01:14:40
Closed captioning:	Check box to display CC outside of the video Note: You can drag the captioning window around and resize it
Description:	Wednesday Afternoon Lecture Series Annual William E. Paul Lecture Investigation of the basic mechanisms by which cytokines and interferons exert their effect led to the discovery of a new paradigm in cell signaling, namely the JAK-STAT pathway. These discoveries revealed a remarkably direct mode of regulating gene expressing but also provided insights into mechanisms of human disease and impetus to generate a new class of therapeutic agents. Now, new investigative tools have made it clearer that cytokines and interferons have a profound epigenomic impact, and they themselves have complex genomic organization. That is, cytokines and cytokine receptors loci are often manifested by super-enhancer architecture and reside in proximity to long noncoding RNAs. In this lecture, Dr. O'Shea will describe how identifying such regulatory regions provides clues to unexpected importance and regulation of function of genes in immune and other cells. For more information go to https://oir.nih.gov/wals

NLM Title:	Cytokine signaling : the more things change, the more they stay the same / John O'Shea.
Author:	O'Shea, John J. National Institutes of Health (U.S.),
Publisher:
Abstract:	(CIT): Wednesday Afternoon Lecture Series Annual William E. Paul Lecture Investigation of the basic mechanisms by which cytokines and interferons exert their effect led to the discovery of a new paradigm in cell signaling, namely the JAK-STAT pathway. These discoveries revealed a remarkably direct mode of regulating gene expressing but also provided insights into mechanisms of human disease and impetus to generate a new class of therapeutic agents. Now, new investigative tools have made it clearer that cytokines and interferons have a profound epigenomic impact, and they themselves have complex genomic organization. That is, cytokines and cytokine receptors loci are often manifested by super-enhancer architecture and reside in proximity to long noncoding RNAs. In this lecture, Dr. O'Shea will describe how identifying such regulatory regions provides clues to unexpected importance and regulation of function of genes in immune and other cells.
Subjects:	Cytokines--physiology Epigenome Gene Expression Signal Transduction--physiology
Publication Types:	Lecture Webcast

NLM Classification:	QW 568
NLM ID:	9918332579406676
CIT Live ID:	43816
Permanent link:	https://videocast.nih.gov/watch=43816

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