Nuclear Incontinence: The Effects of Old Age on the Genome

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Air date:	Wednesday, May 3, 2006, 3:00:00 PM Time displayed is Eastern Time, Washington DC Local
Views:	Total views: 95 * This only includes stats from October 2011 and forward.
Category:	WALS - Wednesday Afternoon Lectures
Runtime:	01:03:43
Closed captioning:	Check box to display CC outside of the video Note: You can drag the captioning window around and resize it
Description:	Our laboratory uses the budding yeast Saccharomyces cerevisiae as a model system to investigate the striking link between increasing age and the incidence of cancer in humans. A hallmark of cancer, genomic instability, is observed in all types of organisms including yeast. We recently discovered that as yeast cells enter the middle-to-late period of their replicative lifespan, they switch to a state of high genomic instability that persists until death. We believe this change represents a fundamental transition in many aging cells. For more information, visit http://www.fhcrc.org/science/labs/gottschling The NIH Director's Wednesday Afternoon Lecture Series includes weekly scientific talks by some of the top researchers in the biomedical sciences worldwide.

NLM Title:	Nuclear incontinence : the effects of old age on the genome / Dan Gottschling.
Author:	Gottschling, Daniel E. National Institutes of Health (U.S.)
Publisher:
Subjects:	Age Factors Genome, Human Neoplasms--etiology Neoplasms--genetics
Publication Types:	Lecture Webcast
NLM Classification:	QZ 202
NLM ID:	101285690
CIT Live ID:	4288
Permanent link:	https://videocast.nih.gov/watch=4288

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