1c:{"metadata":[["$","title","0",{"children":"NIH VideoCast - Genetic Modeling of Neural Tumors in Mice"}],["$","meta","1",{"name":"description","content":"Neurofibromatosis Type 1 (NF1) is a dominantly inherited disease in which mutation of the NF1tumor suppressor either appears de novo or is transmitted through the germ line. Biochemical and mouse knockout studies have demonstrated that\nNF1 is a negative regulator of the ras pathway by acting as rasGap. Dr. Parada has used conventional knockouts and cre/loxP based strategies to model tumor formation in these mice. He will discuss the current understanding of neurofibroma formation, a complex peripheral nerve tumor that is prevalent in NF1.\n

\nFor more information, visit
\nhttp://www8.utsouthwestern.edu/utsw/cda/dept24916/files/72320.html\n
\n
\nThe NIH Director's Wednesday Afternoon Lecture Series includes weekly\nscientific talks by some of the top researchers in the biomedical sciences worldwide.\n
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\nFor more information, visit
\nhttp://www8.utsouthwestern.edu/utsw/cda/dept24916/files/72320.html\n
\n
\nThe NIH Director's Wednesday Afternoon Lecture Series includes weekly\nscientific talks by some of the top researchers in the biomedical sciences worldwide.\n
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\nFor more information, visit
\nhttp://www8.utsouthwestern.edu/utsw/cda/dept24916/files/72320.html\n
\n
\nThe NIH Director's Wednesday Afternoon Lecture Series includes weekly\nscientific talks by some of the top researchers in the biomedical sciences worldwide.\n
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