NIH VideoCast - Casting the Net Wide: the Role of Neutrophils in Chronic Diseases

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Casting the Net Wide: the Role of Neutrophils in Chronic Diseases

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Air date:	Wednesday, June 9, 2021, 3:00:00 PM Time displayed is Eastern Time, Washington DC Local
Views:	Total views: 552 (213 Live, 339 On-demand)
Category:	WALS - Wednesday Afternoon Lectures
Runtime:	01:04:35
Closed captioning:	Check box to display CC outside of the video Note: You can drag the captioning window around and resize it
Description:	Wednesday Afternoon Lecture Series This is the annual G. Burroughs Mider Lecture, established in 1968 in honor of Dr. Mider, the first NIH director of laboratories and clinics, and is presented by an NIH intramural scientist in recognition of their outstanding contributions to biomedical research. Dr. Kaplan's talk is rescheduled from April 2020. Dr. Kapan is chief of the NIAMS Systemic Autoimmunity Branch and also NIAMS Deputy Scientific Director. Her research aims to further the understanding of the pathophysiology and clinical spectrum of systemic autoimmune diseases, such as lupus erythematosus, and to translate this knowledge into better therapies that may improve outcomes for patients with these conditions. Recent discoveries have led to a resurgence of interest in neutrophils as shapers of immune dysregulation and as triggers of organ damage in chronic inflammatory diseases. These important advances have emphasized that neutrophils are significantly more versatile and heterogenous than was previously thought and that they may play fundamental roles in the pathogenesis of systemic autoimmune diseases, such as systemic lupus erythematosus, as well as in the development of vascular damage. These discoveries may have significant implications for the development of new therapies that target dysregulated neutrophil function in chronic inflammatory diseases and in the characterization of biomarkers of disease risk and severity. For more information go to https://oir.nih.gov/wals

NLM Title:	Casting the net wide : the role of neutrophils in chronic diseases / Mariana J. Kaplan.
Author:	Kaplan, Mariana. National Institutes of Health (U.S.),
Publisher:
Abstract:	(CIT): Wednesday Afternoon Lecture Series This is the annual G. Burroughs Mider Lecture, established in 1968 in honor of Dr. Mider, the first NIH director of laboratories and clinics, and is presented by an NIH intramural scientist in recognition of their outstanding contributions to biomedical research. Dr. Kaplan's talk is rescheduled from April 2020. Dr. Kapan is chief of the NIAMS Systemic Autoimmunity Branch and also NIAMS Deputy Scientific Director. Her research aims to further the understanding of the pathophysiology and clinical spectrum of systemic autoimmune diseases, such as lupus erythematosus, and to translate this knowledge into better therapies that may improve outcomes for patients with these conditions. Recent discoveries have led to a resurgence of interest in neutrophils as shapers of immune dysregulation and as triggers of organ damage in chronic inflammatory diseases. These important advances have emphasized that neutrophils are significantly more versatile and heterogenous than was previously thought and that they may play fundamental roles in the pathogenesis of systemic autoimmune diseases, such as systemic lupus erythematosus, as well as in the development of vascular damage. These discoveries may have significant implications for the development of new therapies that target dysregulated neutrophil function in chronic inflammatory diseases and in the characterization of biomarkers of disease risk and severity.
Subjects:	Apoptosis Extracellular Traps Lupus Erythematosus, Systemic--physiopathology Neutrophils--pathology
Publication Types:	Lecture Webcast

NLM Classification:	QZ 194
NLM ID:	9918226873906676
CIT Live ID:	41601
Permanent link:	https://videocast.nih.gov/watch=41601

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