NIH VideoCast - Human Oncogenic Viruses: Nature, Discovery, and Running Around in Circles

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Human Oncogenic Viruses: Nature, Discovery, and Running Around in Circles

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Air date:	Wednesday, May 12, 2021, 3:00:00 PM Time displayed is Eastern Time, Washington DC Local
Views:	Total views: 410 (207 Live, 203 On-demand)
Category:	WALS - Wednesday Afternoon Lectures
Runtime:	00:54:32
Closed captioning:	Check box to display CC outside of the video Note: You can drag the captioning window around and resize it
Description:	Wednesday Afternoon Lecture Series Annual George Khoury Lecture Dr. Chang is Distinguished Professor of Pathology in the Cancer Virology Program, University of Pittsburgh Cancer Institute. Her laboratory performs basic and applied research on viral oncogenesis with efforts focused in three areas: Merkel cell carcinoma and Merkel cell polyomavirus, the latter of which she discovered; Kaposi’s sarcoma-associated herpesvirus, the most common AIDS-associated malignancy; and new pathogen discovery. Seven viruses collectively comprise an important cause of cancer, particularly in less-developed countries and under conditions of immune suppression. Most of these viruses are common infections for which malignancy is a rare consequence. Viral tumors are by nature biological accidents and tumor viruses are generally 'non-permissive' for replication within tumor cells having contracted expression of viral products. These concepts coupled with epidemiological patterns of incidence and advances in technology has facilitated the search for oncogenic viral DNA, mRNA, and even protein as illustrated by Kaposi sarcoma herpesvirus (KSHV) and Merkel cell polyomavirus (MCV). For more information go to https://oir.nih.gov/wals

NLM Title:	Human oncogenic viruses : nature, discovery, and running around in circles / Yuan Chang.
Author:	Chang, Yuan. National Institutes of Health (U.S.),
Publisher:
Abstract:	Dr. Chang is Distinguished Professor of Pathology in the Cancer Virology Program, University of Pittsburgh Cancer Institute. Her laboratory performs basic and applied research on viral oncogenesis with efforts focused in three areas: Merkel cell carcinoma and Merkel cell polyomavirus, the latter of which she discovered; Kaposi's sarcoma-associated herpesvirus, the most common AIDS-associated malignancy; and new pathogen discovery. Seven viruses collectively comprise an important cause of cancer, particularly in less-developed countries and under conditions of immune suppression. Most of these viruses are common infections for which malignancy is a rare consequence. Viral tumors are by nature biological accidents and tumor viruses are generally "non-permissive" for replication within tumor cells having contracted expression of viral products. These concepts coupled with epidemiological patterns of incidence and advances in technology has facilitated the search for oncogenic viral DNA, mRNA, and even protein as illustrated by Kaposi sarcoma herpesvirus (KSHV) and Merkel cell polyomavirus (MCV).
Subjects:	Oncogenic Viruses Tumor Virus Infections
Publication Types:	Lecture Webcast

NLM Classification:	QW 166
NLM ID:	9918226877806676
CIT Live ID:	41588
Permanent link:	https://videocast.nih.gov/watch=41588

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