NIH VideoCast - Demystifying Medicine - Parkinson’s Disease: Advances and Challenges

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Demystifying Medicine - Parkinson’s Disease: Advances and Challenges

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Air date:	Tuesday, April 27, 2021, 4:00:00 PM Time displayed is Eastern Time, Washington DC Local
Views:	Total views: 494 (214 Live, 280 On-demand)
Category:	Demystifying Medicine
Runtime:	01:48:13
Description:	Demystifying Medicine Lecture Series Parkinson's is a long-term degenerative disorder of the central nervous system that causes tremors, slowness of movement, rigidity, and postural instability. The disease may also lead to depression, anxiety, and, in the advanced stages of the disease, dementia. The cause remains unknown, and there is no cure. However, treatment to ameliorate symptoms has advanced in promising ways over the past decade. Ellen Sidransky, M.D., is an NIH senior investigator and chief of the NHGRI Medical Genetics Branch and Section on Molecular Neurogenetics. Her lab aims to understand and to optimize treatment for a rare single gene disorder, Gaucher disease, and to apply the insights gained towards a better understanding of Parkinson disease. Indeed, her research has resulted in the paradigm-shifting discovery of a link between Gaucher disease and Parkinson disease: Mutations in the gene encoding glucocerebrosidase (GBA1) are now the most commonly known genetic risk factor for parkinsonism. This discovery is opening up new treatment possibilities. Dr. Sidransky will show a video of her work with a patient. Michael D. Fox, M.D., Ph.D., is an associate professor of neurology at Harvard Medical School and the founding director of the Center for Brain Circuit Therapeutics at Brigham and Women's Hospital. His research focuses on developing new and improved treatments for brain disease by understanding brain circuits and the effects of neuromodulation. His lab has identified brain circuits mediating symptom relief, including deep brain stimulation for Parkinson's disease. For more information go to https://demystifyingmedicine.od.nih.gov/

Author:	Ellen Sidranski, MD, NHGRI, NIH and Michael D. Fox, MD, PhD, Harvard Medical School

CIT Live ID:	41583
Permanent link:	https://videocast.nih.gov/watch=41583

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