NIH VideoCast - These Viruses Are Forever: Consequences of Retroviral DNA Integration to Aids and Evolution

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These Viruses Are Forever: Consequences of Retroviral DNA Integration to Aids and Evolution

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Air date:	Tuesday, March 16, 2021, 3:00:00 PM Time displayed is Eastern Time, Washington DC Local
Views:	Total views: 524 (294 Live, 230 On-demand)
Category:	WALS - Wednesday Afternoon Lectures
Runtime:	01:16:17
Closed captioning:	Check box to display CC outside of the video Note: You can drag the captioning window around and resize it
Description:	WALS This WALS lecture also is part of the Demystifying Medicine course series. John Coffin is an American Cancer Society Research Professor at Tufts University School of Medicine. He also maintains a joint position as a special advisor at the NCI Center for Cancer Research at NCI. His research interests revolve around obtaining a better understanding of the interaction of retroviruses with their host cells and organisms. He uses simple retroviruses (avian and murine viruses) as well as HIV to elucidate the nature of the retrovirus-receptor interaction. Unique among pathogens of eukaryotes, retroviruses are distinctive in their replication through an obligate integrated DNA intermediate — the provirus — resulting in many biological consequences unique to this virus group. This talk will focus on two such consequences: the rich "fossil record" of infection of our primate ancestors for more than 100 million years in the form of endogenous proviruses; and our inability, despite the availability of highly effective viral treatments, to cure HIV infection. For more information go to https://oir.nih.gov/wals

NLM Title:	These viruses are forever : consequences of retroviral DNA integration to aids and evolution / John Coffin.
Author:	Coffin, John M.
Publisher:
Abstract:	(CIT): WALS This WALS lecture also is part of the Demystifying Medicine course series. John Coffin is an American Cancer Society Research Professor at Tufts University School of Medicine. He also maintains a joint position as a special advisor at the NCI Center for Cancer Research at NCI. His research interests revolve around obtaining a better understanding of the interaction of retroviruses with their host cells and organisms. He uses simple retroviruses (avian and murine viruses) as well as HIV to elucidate the nature of the retrovirus-receptor interaction. Unique among pathogens of eukaryotes, retroviruses are distinctive in their replication through an obligate integrated DNA intermediate -- the provirus -- resulting in many biological consequences unique to this virus group. This talk will focus on two such consequences: the rich "fossil record" of infection of our primate ancestors for more than 100 million years in the form of endogenous proviruses; and our inability, despite the availability of highly effective viral treatments, to cure HIV infection.
Subjects:	Endogenous Retroviruses HIV Virus Integration
Publication Types:	Lecture Webcast

NLM Classification:	QW 168.5.R18
NLM ID:	101778066
CIT Live ID:	41446
Permanent link:	https://videocast.nih.gov/watch=41446

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