NIH VideoCast - Quasi-species Suppression of Viral Drug Resistance

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Quasi-species Suppression of Viral Drug Resistance

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Air date:	Wednesday, March 3, 2021, 3:00:00 PM Time displayed is Eastern Time, Washington DC Local
Views:	Total views: 332 (209 Live, 123 On-demand)
Category:	WALS - Wednesday Afternoon Lectures
Runtime:	00:59:09
Closed captioning:	Check box to display CC outside of the video Note: You can drag the captioning window around and resize it
Description:	NIH Director’s Wednesday Afternoon Lecture Series This is the annual George Khoury Lecture, which honors the memory of Dr. George Khoury (1943–1987), a highly regarded NIH virologist and caring mentor of the postdoctoral fellows in his laboratory. Dr. Karla Kirkegaard, Ph.D., is the Violetta L. Horton Research Professor of Genetics at the Stanford University School of Medicine. Her laboratory focuses on identification of dominant drug targets for antiviral design, such as small molecules that stabilize oligomeric assemblages. A past recipient of the NIH Director's Pioneer Award, Dr. Kirkegaard combines her interests in biochemistry, cell biology, and genetics in the study of RNA virology, using poliovirus and other positive-strand RNA viruses to understand the cell biology of viral infections and the genetics of viral variability. The spectre of drug resistance renders the development of antivirals difficult, especially in RNA viruses whose genome replication is highly error prone. Karla Kirkegaard's lab has been working to develop principles by which the outgrowth of drug-resistant viruses can be thwarted through the choice of noncanonical antiviral targets. For more information go to https://oir.nih.gov/wals

Author:	Karla Kirkegaard, Ph.D., Violetta L. Horton Research Professor of Genetics, Stanford University School of Medicine

CIT Live ID:	41441
Permanent link:	https://videocast.nih.gov/watch=41441

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