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\nDr. Wherry is the Richard and Barbara Schiffrin President's Distinguished Professor at the Perelman School of Medicine, University of Pennsylvania, Philadelphia. He studies T cell exhaustion in chronic infections and cancer and has helped define molecular mechanisms of T cell exhaustion through transcriptional and epigenetic studies, including studies on the mechanisms by which immunoregulatory \"checkpoint\" pathways such as PD-1 control T cell exhaustion. \n

\nDr. Wherry has helped uncover key features of inhibitory receptor blockade and co-blockade to reverse T cell exhaustion using transcriptional profiling, genomics, computational biology and multiparameter flow cytometry to understand the nature and reversibility of T cell exhaustion in preclinical and clinical settings. His laboratory has used these techniques to comprehensively study immune responses and immunophenotypes in response to SARS-CoV-2, which will be the topic of his lecture.\n"}],["$","meta","2",{"name":"publisher","content":"National Institutes of Health"}],["$","meta","3",{"property":"og:title","content":"NIH VideoCast - Immune Profiling to Understand COVID-19 Pathogenesis"}],["$","meta","4",{"property":"og:description","content":"NIH COVID-19 Scientific Interest Group \n

\nDr. Wherry is the Richard and Barbara Schiffrin President's Distinguished Professor at the Perelman School of Medicine, University of Pennsylvania, Philadelphia. He studies T cell exhaustion in chronic infections and cancer and has helped define molecular mechanisms of T cell exhaustion through transcriptional and epigenetic studies, including studies on the mechanisms by which immunoregulatory \"checkpoint\" pathways such as PD-1 control T cell exhaustion. \n

\nDr. Wherry has helped uncover key features of inhibitory receptor blockade and co-blockade to reverse T cell exhaustion using transcriptional profiling, genomics, computational biology and multiparameter flow cytometry to understand the nature and reversibility of T cell exhaustion in preclinical and clinical settings. His laboratory has used these techniques to comprehensively study immune responses and immunophenotypes in response to SARS-CoV-2, which will be the topic of his lecture.\n"}],["$","meta","5",{"property":"og:url","content":"https://uat.d1rkikwu4q8tg.amplifyapp.com/watch/be57bcf6-d5db-11f0-9cf9-12c45c580ad9"}],["$","meta","6",{"property":"og:site_name","content":"NIH VideoCast"}],["$","meta","7",{"property":"og:image","content":"https://nihcit.rev.vbrick.com/api/v2/media/videos/thumbnails/e852cc9c-3022-4bc0-b113-9ec6e20a04f0.jpg"}],["$","meta","8",{"property":"og:type","content":"website"}],["$","meta","9",{"name":"twitter:card","content":"summary_large_image"}],["$","meta","10",{"name":"twitter:title","content":"NIH VideoCast - Immune Profiling to Understand COVID-19 Pathogenesis"}],["$","meta","11",{"name":"twitter:description","content":"NIH COVID-19 Scientific Interest Group \n

\nDr. Wherry is the Richard and Barbara Schiffrin President's Distinguished Professor at the Perelman School of Medicine, University of Pennsylvania, Philadelphia. He studies T cell exhaustion in chronic infections and cancer and has helped define molecular mechanisms of T cell exhaustion through transcriptional and epigenetic studies, including studies on the mechanisms by which immunoregulatory \"checkpoint\" pathways such as PD-1 control T cell exhaustion. \n

\nDr. Wherry has helped uncover key features of inhibitory receptor blockade and co-blockade to reverse T cell exhaustion using transcriptional profiling, genomics, computational biology and multiparameter flow cytometry to understand the nature and reversibility of T cell exhaustion in preclinical and clinical settings. His laboratory has used these techniques to comprehensively study immune responses and immunophenotypes in response to SARS-CoV-2, which will be the topic of his lecture.\n"}],"$L22","$L23","$L24"],"error":null,"digest":"$undefined"}