NIH VideoCast - Immune Profiling to Understand COVID-19 Pathogenesis

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Immune Profiling to Understand COVID-19 Pathogenesis

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Air date:	Thursday, November 5, 2020, 12:00:00 PM Time displayed is Eastern Time, Washington DC Local
Views:	Total views: 1,082 (625 Live, 457 On-demand)
Category:	COVID-19
Runtime:	01:02:34
Closed captioning:	Check box to display CC outside of the video Note: You can drag the captioning window around and resize it
Description:	NIH COVID-19 Scientific Interest Group Dr. Wherry is the Richard and Barbara Schiffrin President's Distinguished Professor at the Perelman School of Medicine, University of Pennsylvania, Philadelphia. He studies T cell exhaustion in chronic infections and cancer and has helped define molecular mechanisms of T cell exhaustion through transcriptional and epigenetic studies, including studies on the mechanisms by which immunoregulatory "checkpoint" pathways such as PD-1 control T cell exhaustion. Dr. Wherry has helped uncover key features of inhibitory receptor blockade and co-blockade to reverse T cell exhaustion using transcriptional profiling, genomics, computational biology and multiparameter flow cytometry to understand the nature and reversibility of T cell exhaustion in preclinical and clinical settings. His laboratory has used these techniques to comprehensively study immune responses and immunophenotypes in response to SARS-CoV-2, which will be the topic of his lecture.

NLM Title:	Immune profiling to understand COVID-19 pathogenesis / John Wherry.
Author:	Wherry, E John. National Institutes of Health (U.S.). COVID-19 Scientific Interest Group,
Publisher:
Abstract:	(CIT): Dr. Wherry is the Richard and Barbara Schiffrin President's Distinguished Professor at the Perelman School of Medicine, University of Pennsylvania, Philadelphia. He studies T cell exhaustion in chronic infections and cancer and has helped define molecular mechanisms of T cell exhaustion through transcriptional and epigenetic studies, including studies on the mechanisms by which immunoregulatory "checkpoint" pathways such as PD-1 control T cell exhaustion. Dr. Wherry has helped uncover key features of inhibitory receptor blockade and co-blockade to reverse T cell exhaustion using transcriptional profiling, genomics, computational biology and multiparameter flow cytometry to understand the nature and reversibility of T cell exhaustion in preclinical and clinical settings. His laboratory has used these techniques to comprehensively study immune responses and immunophenotypes in response to SARS-CoV-2, which will be the topic of his lecture.
Subjects:	COVID-19--immunology COVID-19--physiopathology Immunologic Techniques T-Lymphocytes--immunology
Publication Types:	Lecture Webcast

NLM Classification:	WC 505
NLM ID:	101774273
CIT Live ID:	38868
Permanent link:	https://videocast.nih.gov/watch=38868

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