NIH VideoCast - NIGMS Director's Early-Career Investigator Lecture: Microbes, Metals, Music, and Lessons in Disproving Your Hypothesis

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NIGMS Director's Early-Career Investigator Lecture: Microbes, Metals, Music, and Lessons in Disproving Your Hypothesis

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Air date:	Wednesday, October 14, 2020, 1:00:00 PM Time displayed is Eastern Time, Washington DC Local
Views:	Total views: 611 (226 Live, 385 On-demand)
Category:	Special
Runtime:	01:02:16
Closed captioning:	Check box to display CC outside of the video Note: You can drag the captioning window around and resize it
Description:	NIGMS Director's Early-Career Investigator Lecture At the host/pathogen interface, bacteria must acquire those metals from within. While host and microbe battle over metals like iron and manganese, not all host utilized metals are desirable for bacteria. In fact, copper is largely toxic to them; a fact that is exploited by the host. As such, bacteria devote significant resources to maintain metal homeostasis through systems that address the stress of excess or deficiency. Here, Dr. Johnson will look at copper stress affected and overcoming systems, how bacteria use metals to perceive their environment, and how we can take advantage of it all to develop new therapeutics. For more information go to https://www.nigms.nih.gov/News/meetings/Pages/2020-nigms-directors-early-career-investigator-lecture.aspx

NLM Title:	Microbes, metals, music, and lessons in disproving your hypothesis / Michael D.L. Johnson.
Author:	Johnson, Michael D L. National Institute of General Medical Sciences (U.S.),
Publisher:
Abstract:	(CIT): At the host/pathogen interface, bacteria must acquire those metals from within. While host and microbe battle over metals like iron and manganese, not all host utilized metals are desirable for bacteria. In fact, copper is largely toxic to them; a fact that is exploited by the host. As such, bacteria devote significant resources to maintain metal homeostasis through systems that address the stress of excess or deficiency. Here, Dr. Johnson will look at copper stress affected and overcoming systems, how bacteria use metals to perceive their environment, and how we can take advantage of it all to develop new therapeutics.
Subjects:	Bacteria--pathogenicity Bacterial Physiological Phenomena Copper--metabolism Drug Discovery Host-Pathogen Interactions
Publication Types:	Lecture Webcast

NLM Classification:	QW 52
NLM ID:	101773036
CIT Live ID:	38707
Permanent link:	https://videocast.nih.gov/watch=38707

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