NIH VideoCast - NIH COVID-19 Lecture: SARS-CoV-2 T Cell Responses in Exposed and Non-Exposed Subjects

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NIH COVID-19 Lecture: SARS-CoV-2 T Cell Responses in Exposed and Non-Exposed Subjects

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Air date:	Wednesday, July 29, 2020, 3:00:00 PM Time displayed is Eastern Time, Washington DC Local
Views:	Total views: 1,319 (724 Live, 595 On-demand)
Category:	COVID-19
Runtime:	01:02:48
Closed captioning:	Check box to display CC outside of the video Note: You can drag the captioning window around and resize it
Description:	NIH COVID-19 Lecture Series Dr. Sette will review data examining the nature and specificity of T cell responses to SARS-CoV-2 from convalescent and acute donors, and in non-exposed subjects. Over the past three decades, the Sette lab has defined in chemical terms the specific structures that the immune system recognizes, and it has capitalized on this knowledge to measure and understand immune responses. This approach uses epitopes as specific probes to define the immune signatures associated with productive/protective immunity versus deficient immunity/immunopathology. Turning to SARS-CoV-2, Dr. Sette and his colleagues applied this approach to provide the one of the first assessments of whether the immune system can mount a substantial and lasting response, finding evidence of T cell reactivity against and pre-existing immunity to SARS-CoV-2. Dr. Sette will highlight these and other findings in his talk.

NLM Title:	SARS-CoV-2 T cell responses in exposed and non-exposed subjects / Alessandro Sette.
Author:	Sette, Alessandro. National Institutes of Health (U.S.). COVID-19 Scientific Interest Group,
Publisher:
Abstract:	(CIT): NIH COVID-19 Lecture Series Dr. Sette will review data examining the nature and specificity of T cell responses to SARS-CoV-2 from convalescent and acute donors, and in non-exposed subjects. Over the past three decades, the Sette lab has defined in chemical terms the specific structures that the immune system recognizes, and it has capitalized on this knowledge to measure and understand immune responses. This approach uses epitopes as specific probes to define the immune signatures associated with productive/protective immunity versus deficient immunity/immunopathology. Turning to SARS-CoV-2, Dr. Sette and his colleagues applied this approach to provide the one of the first assessments of whether the immune system can mount a substantial and lasting response, finding evidence of T cell reactivity against and pre-existing immunity to SARS-CoV-2. Dr. Sette will highlight these and other findings in his talk.
Subjects:	Betacoronavirus--immunology CD4-Positive T-Lymphocytes--immunology CD8-Positive T-Lymphocytes--immunology Coronavirus Infections--immunology Pneumonia, Viral--immunology
Publication Types:	Lecture Webcast

NLM Classification:	WC 505
NLM ID:	101770501
CIT Live ID:	38106
Permanent link:	https://videocast.nih.gov/watch=38106

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