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State-Dependence of Hippocampal Synaptic Plasticity
Monday, February 7, 2005,
12:00:00 PM Time displayed is Eastern Time, Washington DC Local
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The Madison laboratory uses electrophysiological techniques to study the mechanisms of synaptic transmission and plasticity in the mammalian hippocampus. The main focus of the lab is the study of long term potentiation (LTP) and long-term depression (LTD), the most widely studied and compelling models for the mechanisms underlying memory formation in the mammalian central nervous system. Madison studies these plastic processes primarily in the very small populations of synapses formed between individual pairs of hippocampal neurons. These small population measures, combined with the introduction of mutant genes into the pre and/or postsynaptic member of a cell pair provide a powerful methodology for dissecting the mechanisms of these plastic processes.