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Neurodegeneration: mechanisms to medicines

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Air date: Monday, March 9, 2020, 12:00:00 PM
Time displayed is Eastern Time, Washington DC Local
Views: Total views: 183 (56 Live, 127 On-demand)
Category: Neuroscience
Runtime: 00:56:35
Description: NIH Neuroscience Series Seminar

Dr. Mallucci lab is interested in understanding mechanisms of neurodegeneration. The central theme is the identification of common pathways across the spectrum of these disorders (which include Alzheimer's and related diseases) that are relevant for both mechanistic insights and therapy. They focus both on ‘toxic’ processes that can be targeted to prevent neuronal death, and on regenerative processes that can be harnessed for repair. Using mouse models, they described the pathogenic role of the unfolded protein response (UPR) in neurodegeneration, which led to the discovery of the first small molecule - an inhibitor of this pathway - to prevent neurodegeneration in vivo. They also recently discovered the phenomenon of failure of synaptic repair processes in neurodegeneration and the underlying mechanisms: failure of another stress response involving 'cold shock' proteins, which they have successfully harnessed for neuroprotection. They aim to translate this research for new treatments for dementia.

For more information go to https://neuroscience.nih.gov/ninds/Home.aspx
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Author: Giovanna Mallucci, MD, PhD, University of Cambridge
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CIT Live ID: 35613
Permanent link: https://videocast.nih.gov/watch=35613