NIH VideoCast - Demystifying Medicine - Tracing Memories from Molecular Footprints to Alzheimer's Disease

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Demystifying Medicine - Tracing Memories from Molecular Footprints to Alzheimer's Disease

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Air date:	Tuesday, February 25, 2020, 4:00:00 PM Time displayed is Eastern Time, Washington DC Local
Views:	Total views: 384 (150 Live, 234 On-demand)
Category:	Demystifying Medicine
Runtime:	01:43:19
Closed captioning:	Check box to display CC outside of the video Note: You can drag the captioning window around and resize it
Description:	Demystifying Medicine Lecture Series Alzheimer's disease is a topic on everyone's mind. Few among us are untouched by the disease. Most of us know someone affected by the condition. Many of us care for a loved one with Alzheimer's. Many of us worry that the memory-stealing affliction will come for us, too. More than 30 million people worldwide live with Alzheimer's, and more than 2 million die each year from it. Most troubling is the fact that one promising treatment after another has failed to live up to hope, and we are still left with no cure or suitable treatment to slow the progression despite decades of effort. Lorna Role, the NINDS Scientific Director, recently recruited from State University of New York at Stony Brook, has made breakthrough discoveries concerning the brain's cholinergic system over a lifespan. Cholinergic signaling is essential for attention, cognitive processing, and memory and is compromised in neurological disorders such as Alzheimer's and Parkinson's disease. She also oversees the nearly 50 labs in the NINDS intramural program, many of which study Alzheimer's from various angles. Dimitrios Kapogiannis is an investigator in the NIA Cellular & Molecular Neurosciences Section, based in Baltimore. His group is developing biomarkers for preclinical diagnosis and for demonstrating target engagement in clinical trials. In a series of elegant case-control studies, Kapogiannis identified candidate biomarkers for AD diagnosis from extracellular vesicles enriched for neuronal and astrocytic origin. Together, the speakers will elucidate how the NIH hopes to make Alzheimer's a distant memory for generations to come. The Demystifying Medicine Lecture Series is designed to help bridge the gap between advances in biology and their applications to major human diseases. The lectures include presentations of patients, pathology, diagnosis, and therapy in the context of major diseases and current research. All clinicians, trainees including fellows, medical students, Ph.D. students, and other healthcare and research professionals are welcome to attend. For more information go to https://demystifyingmedicine.od.nih.gov

NLM Title:	Demystifying medicine. Tracing memories from molecular footprints to Alzheimer's disease / Dimitrios Kapogiannis, Lorna Role.
Author:	Kapogiannis, Dimitrios. Role, Lorna. National Institutes of Health (U.S.),
Publisher:
Abstract:	(CIT): Alzheimer's disease is a topic on everyone's mind. Few among us are untouched by the disease. Most of us know someone affected by the condition. Many of us care for a loved one with Alzheimer's. Many of us worry that the memory-stealing affliction will come for us, too. More than 30 million people worldwide live with Alzheimer's, and more than 2 million die each year from it. Most troubling is the fact that one promising treatment after another has failed to live up to hope, and we are still left with no cure or suitable treatment to slow the progression despite decades of effort.
Subjects:	Alzheimer Disease--genetics Memory, Episodic Models, Molecular Semantics
Publication Types:	Lecture Webcast

NLM Classification:	WT 155
NLM ID:	101763754
CIT Live ID:	35584
Permanent link:	https://videocast.nih.gov/watch=35584

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