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Spinal Motoneurons: Sherrington’s ‘Final Common Pathway’ or Motor Network Regulators?

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Air date: Monday, October 28, 2019, 12:00:00 PM
Time displayed is Eastern Time, Washington DC Local
Views: Total views: 92 (14 Live, 78 On-demand)
Category: Neuroscience
Runtime: 01:04:50
Description: NIH Neuroscience Series Seminar

Research in his lab is concerned with the development and operation of circuits in the spinal cord. They are currently devoting most of effort to understanding the organization of spinal circuitry involved in locomotion of the neonatal mouse. They are particularly interested in understanding the role of motoneurons in the operation of locomotor networks and the mechanisms responsible for the excitatory effects of motoneurons within the spinal cord.

Their current effort is focused on understanding how motoneurons trigger and modulate the locomotor rhythm in the neonatal spinal cord. This involves several techniques including, whole cell patch clamping, calcium and voltage imaging, optogenetics and immunocytochemistry.

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Author: Michael O'Donovan, M.D., Ph.D., Developmental Neurobiology Section, NINDS, NIH
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CIT Live ID: 34828
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