Bacterial Pathogens: Hijacking Eukaryotic Signal Transduction Systems

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Air date:	Wednesday, May 4, 2005, 3:00:00 PM Time displayed is Eastern Time, Washington DC Local
Views:	Total views: 111 * This only includes stats from October 2011 and forward.
Category:	WALS - Wednesday Afternoon Lectures
Runtime:	00:55:18
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Description:	A Yersinia effector known as YopT and a Pseudomonas avirulence protein known as AvrPphB define a family of 19 proteins involved in bacterial pathogenesis. We show that both YopT and AvrPphB are cysteine proteases, and their proteolytic activities are dependent upon the invariant C/H/D residues conserved in the entire YopT family. YopT cleaves the posttranslationally modified Rho GTPases near their carboxyl termini, releasing them from the membrane. This leads to the disruption of actin cytoskeleton in host cells. For more information, visit http://medicine.ucsd.edu/molpath/faculty_profile.php?faculty_id=72 The NIH Director's Wednesday Afternoon Lecture Series includes weekly scientific talks by some of the top researchers in the biomedical sciences worldwide.

Author:	Jack Dixon, Ph.D, University of California San Diego
CIT Live ID:	3453
Permanent link:	https://videocast.nih.gov/watch=3453

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