1c:{"metadata":[["$","title","0",{"children":"NIH VideoCast - Bacterial Pathogens: Hijacking Eukaryotic Signal Transduction Systems"}],["$","meta","1",{"name":"description","content":"A Yersinia effector known as YopT and a Pseudomonas avirulence protein known as AvrPphB define a family of 19 proteins involved in bacterial pathogenesis. We show that both YopT and AvrPphB are cysteine proteases, and their proteolytic activities are dependent upon the invariant C/H/D residues conserved in the entire YopT family. YopT cleaves the posttranslationally modified Rho GTPases near their carboxyl termini, releasing them from the membrane. This leads to the disruption of actin cytoskeleton in host cells.\n
\n
\nFor more information, visit
\nhttp://medicine.ucsd.edu/molpath/faculty_profile.php?faculty_id=72\n
\n
\nThe NIH Director's Wednesday Afternoon Lecture Series includes weekly\nscientific talks by some of the top researchers in the biomedical sciences worldwide.\n
"}],["$","meta","2",{"name":"publisher","content":"National Institutes of Health"}],["$","meta","3",{"property":"og:title","content":"NIH VideoCast - Bacterial Pathogens: Hijacking Eukaryotic Signal Transduction Systems"}],["$","meta","4",{"property":"og:description","content":"A Yersinia effector known as YopT and a Pseudomonas avirulence protein known as AvrPphB define a family of 19 proteins involved in bacterial pathogenesis. We show that both YopT and AvrPphB are cysteine proteases, and their proteolytic activities are dependent upon the invariant C/H/D residues conserved in the entire YopT family. YopT cleaves the posttranslationally modified Rho GTPases near their carboxyl termini, releasing them from the membrane. This leads to the disruption of actin cytoskeleton in host cells.\n
\n
\nFor more information, visit
\nhttp://medicine.ucsd.edu/molpath/faculty_profile.php?faculty_id=72\n
\n
\nThe NIH Director's Wednesday Afternoon Lecture Series includes weekly\nscientific talks by some of the top researchers in the biomedical sciences worldwide.\n
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\n
\nFor more information, visit
\nhttp://medicine.ucsd.edu/molpath/faculty_profile.php?faculty_id=72\n
\n
\nThe NIH Director's Wednesday Afternoon Lecture Series includes weekly\nscientific talks by some of the top researchers in the biomedical sciences worldwide.\n
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