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Life Cycle of Human Papilloma Viruses in Differentiating Epithelia
Wednesday, October 13, 2004,
3:00:00 PM Time displayed is Eastern Time, Washington DC Local
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The productive life cycle of human papillomaviruses is dependent upon epithelial differentiation with synthesis of new virions restricted to highly differentiated suprabasal cells. Papillomaviruses are small DNA viruses that induce a variety of proliferative lesions in humans. Of the 100 types of human papillomaviruses that have been identified, a subset are associated at a high frequency with anogenital cancers and these are referred to as the high risk types Viral infection occurs into stratified epithelial cells and results in an altered pattern of differentiation from that seen in normal cells.