||The proliferation, survival and branching of mammary epithelial cells is highly influenced by interactions of the epithelial cells with other cells, with their surrounding extracellular matrix, and with hormones and other regulatory factors in their microenvironment. Oncogenes, tumor suppressor genes, and factors in the microenvironment allow cells to escape regulatory controls imposed on cells in their natural tissue environment, thus leading to progressive changes in the organization of cells, their proliferative capacity, their sensitivity to stress-induced death and their ability to escape from their natural environment.
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