Skip Navigation

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you’ve safely connected to the .gov website. Share sensitive information only on official, secure websites.

Control of Hunger by Arcuate (ARC) → Paraventricular (PVH) Hypothalamic Circuits

Loading video...

382 Views

Air date: Monday, November 19, 2018, 12:00:00 PM
Time displayed is Eastern Time, Washington DC Local
Views: Total views: 382 (27 Live, 355 On-demand)
Category: Neuroscience
Runtime: 00:58:37
Description: NIH Neuroscience Series Seminar

Dr. Lowell lab utilizes genetic engineering techniques in mice, in conjunction with electrophysiology, optogenetics, pharmacogenetics and rabies mapping, to elucidate central neurocircuits controlling feeding behavior, body weight homeostasis, and fuel metabolism. Specifically, transgenic, knockout, knockin, and cre-dependent AAV viral approaches (for delivery of optogenetic, DREADD and monosynaptic rabies reagents) are used to manipulate and map neuronal circuits. The goal of these studies is to link neurobiologic processes within defined sets of neurons with specific behaviors and physiologic responses. The ultimate goal is to mechanistically understand the “neurocircuit basis” for regulation of food intake, energy expenditure and glucose homeostasis. Given their expertise in gene knockout and transgenic technology, they can efficiently and rapidly create numerous lines of genetically engineered mice, important examples being neuron-specific ires-Cre knockin mice, which enable cre-dependent AAV technology. This allows them to bring novel, powerful approaches to bear on the neural circuits underlying behavior and metabolism. Their combined use of mouse genetic engineering, brain slice electrophysiology, and whole animal physiology is ideally suited to studying these problems.

For more information go to https://neuroscience.nih.gov/neuroseries/Home.aspx
Author: Bradford Lowell, M.D., Ph.D., Harvard University
 
CIT Live ID: 28079
Permanent link: https://videocast.nih.gov/watch=28079

Related Videos...

Click Here to Play Video.
05:38:58
Women's Health Interdisciplinary Research Symposium (Day 2)
[Women's Health]
10/5/2004
Click Here to Play Video.
06:36:51
Annual meeting of the National Centers for Systems Biology (Day 1)
[Conferences]
7/13/2009
Click Here to Play Video.
06:44:19
The National Cancer Advisory Board Meeting - December 2009 (Day 1)
[National Cancer Advisory Board]
12/1/2009
Click Here to Play Video.
07:18:32
RAS Initiative Symposium (Day 2)
[NIH Only]
12/16/2015
Click Here to Play Video.
04:47:08
Malnutrition in Clinical Settings: Research Gaps and Opportunities - Day 4
[Conferences]
9/19/2022
Click Here to Play Video.
07:03:04
The Evolution of Mental Health Research
[Conferences]
9/13/2023
Click Here to Play Video.
04:53:32
2nd Annual NIH Investigator Meeting on Interoception Research
[Conferences]
11/11/2023
Click Here to Play Video.
01:02:07
NIH Director's Seminar Series - The Paraventricular Thalamus: An Integrative Node Underlying Homeostatic Behavior
[NIH Director's Seminars]
3/8/2024
Click Here to Play Video.
00:56:36
Neural circuits that control ingestion
[HHS Only]
4/15/2024
Click Here to Play Video.
03:45:16
National Advisory Council on Aging
[Advisory Boards and Councils]
9/19/2024