NIH VideoCast - Cell and genome organization in mitosis, development, and homeostasis

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Cell and genome organization in mitosis, development, and homeostasis

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Air date:	Wednesday, June 20, 2018, 3:00:00 PM Time displayed is Eastern Time, Washington DC Local
Views:	Total views: 275 (115 Live, 160 On-demand)
Category:	WALS - Wednesday Afternoon Lectures
Runtime:	01:07:05
Closed captioning:	Check box to display CC outside of the video Note: You can drag the captioning window around and resize it
Description:	NIH Director’s Wednesday Afternoon Lecture Series I began my research career studying how microtubules regulate various cellular processes, especially microtubule assembly, mitotic spindle assembly, and chromosome segregation. As a PhD student in Dr. Berl Oakley’s lab, my study of g-tubulin has inspired me to use biochemical approaches to investigate the mechanism of microtubule nucleation as a postdoctoral fellow in Drs. Bruce Alberts and Tim Mitchison’s labs at UCSF. This has led to the discovery of the g-tubulin ring complex (gTuRC) and the demonstration of its microtubule-nucleating activity from purified tubulins. After establishing my lab, we discovered the role of RanGTPase in regulating spindle assembly in mitosis. Our more recent study of the mitotic spindle matrix has led to the finding that the nuclear lamin-B is part of the spindle matrix. We show that lamin-B plays a role in mitotic spindle morphogenesis and spindle orientation. In recent years, our research has expanded into studying the role of lamins in the interphase nucleus. By analyzing lamin deletions in mice, mouse ES cells, and various Drosophila stem cells, we have shown that lamins play important roles in organogenesis during development. Additionally, we show that lamin-B prevents immunosenescence and system inflammation upon organismal aging by maintaining the heterochromatin in immune organs.

NLM Title:	Cell and genome organization in mitosis, development, and homeostasis / Yixian Zheng.
Author:	Zheng, Yixian. National Institutes of Health (U.S.),
Publisher:
Abstract:	(CIT): NIH Director"s Wednesday Afternoon Lecture Series I began my research career studying how microtubules regulate various cellular processes, especially microtubule assembly, mitotic spindle assembly, and chromosome segregation. As a PhD student in Dr. Berl Oakley"s lab, my study of g-tubulin has inspired me to use biochemical approaches to investigate the mechanism of microtubule nucleation as a postdoctoral fellow in Drs. Bruce Alberts and Tim Mitchison"s labs at UCSF. This has led to the discovery of the g-tubulin ring complex (gTuRC) and the demonstration of its microtubule-nucleating activity from purified tubulins. After establishing my lab, we discovered the role of RanGTPase in regulating spindle assembly in mitosis. Our more recent study of the mitotic spindle matrix has led to the finding that the nuclear lamin-B is part of the spindle matrix. We show that lamin-B plays a role in mitotic spindle morphogenesis and spindle orientation. In recent years, our research has expanded into studying the role of lamins in the interphase nucleus. By analyzing lamin deletions in mice, mouse ES cells, and various Drosophila stem cells, we have shown that lamins play important roles in organogenesis during development. Additionally, we show that lamin-B prevents immunosenescence and system inflammation upon organismal aging by maintaining the heterochromatin in immune organs.
Subjects:	Cellular Structures--physiology Genome--physiology Mitosis--physiology
Publication Types:	Lecture Webcast

NLM Classification:	QU 375
NLM ID:	101729825
CIT Live ID:	28002
Permanent link:	https://videocast.nih.gov/watch=28002

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