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\nDr. Geissman's lab has studied the diseases of monocytes and macrophages and has elucidated several important aspects of their developmental origin, homeostasis, and functions. This includes the description of the two main functional subsets of monocytes in mice, the common bone marrow progenitor for dendritic cells and monocyte/macrophages (MDP), and the yolk Sac Erythro-Myeloid Progenitor (YS EMP) for tissue resident macrophage. The Geissman lab developed novel experimental approaches to study their myeloid cell differentiation and functions in vivo. In recent works the lab demonstrated that a somatic mutation in EMP causes a neurodegenerative disease mediated by mutated microglia. In pursuing these studies, the lab hopes to unveil genetic basis for the roles of macrophage in degenerative, inflammatory, and tumoral diseases.>For more information go to https://oir.nih.gov/wals/2017-2018/"}],["$","meta","2",{"name":"publisher","content":"National Institutes of Health"}],["$","meta","3",{"property":"og:title","content":"NIH VideoCast - Of Bones, Brain, and Fat: Macrophages and the Control of Homeostasis"}],["$","meta","4",{"property":"og:description","content":"NIH Director's Wednesday Afternoon Lecture Series\n

\nDr. Geissman's lab has studied the diseases of monocytes and macrophages and has elucidated several important aspects of their developmental origin, homeostasis, and functions. This includes the description of the two main functional subsets of monocytes in mice, the common bone marrow progenitor for dendritic cells and monocyte/macrophages (MDP), and the yolk Sac Erythro-Myeloid Progenitor (YS EMP) for tissue resident macrophage. The Geissman lab developed novel experimental approaches to study their myeloid cell differentiation and functions in vivo. In recent works the lab demonstrated that a somatic mutation in EMP causes a neurodegenerative disease mediated by mutated microglia. In pursuing these studies, the lab hopes to unveil genetic basis for the roles of macrophage in degenerative, inflammatory, and tumoral diseases.>For more information go to https://oir.nih.gov/wals/2017-2018/"}],["$","meta","5",{"property":"og:url","content":"https://uat.d1rkikwu4q8tg.amplifyapp.com/watch/b471be10-d5db-11f0-9cf9-12c45c580ad9"}],["$","meta","6",{"property":"og:site_name","content":"NIH VideoCast"}],["$","meta","7",{"property":"og:image","content":"https://nihcit.rev.vbrick.com/api/v2/media/videos/thumbnails/10414880-69fe-4e83-bda7-f4fddb95cc1f.jpg"}],["$","meta","8",{"property":"og:type","content":"website"}],["$","meta","9",{"name":"twitter:card","content":"summary_large_image"}],["$","meta","10",{"name":"twitter:title","content":"NIH VideoCast - Of Bones, Brain, and Fat: Macrophages and the Control of Homeostasis"}],["$","meta","11",{"name":"twitter:description","content":"NIH Director's Wednesday Afternoon Lecture Series\n

\nDr. Geissman's lab has studied the diseases of monocytes and macrophages and has elucidated several important aspects of their developmental origin, homeostasis, and functions. This includes the description of the two main functional subsets of monocytes in mice, the common bone marrow progenitor for dendritic cells and monocyte/macrophages (MDP), and the yolk Sac Erythro-Myeloid Progenitor (YS EMP) for tissue resident macrophage. The Geissman lab developed novel experimental approaches to study their myeloid cell differentiation and functions in vivo. In recent works the lab demonstrated that a somatic mutation in EMP causes a neurodegenerative disease mediated by mutated microglia. In pursuing these studies, the lab hopes to unveil genetic basis for the roles of macrophage in degenerative, inflammatory, and tumoral diseases.>For more information go to https://oir.nih.gov/wals/2017-2018/"}],"$L22","$L23","$L24"],"error":null,"digest":"$undefined"}