NIH VideoCast - From protein folding to cognition: a serendipitous path of discovery

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From protein folding to cognition: a serendipitous path of discovery

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Air date:	Wednesday, April 19, 2017, 3:00:00 PM Time displayed is Eastern Time, Washington DC Local
Views:	Total views: 407 (118 Live, 289 On-demand)
Category:	WALS - Wednesday Afternoon Lectures
Runtime:	01:02:22
Closed captioning:	Check box to display CC outside of the video Note: You can drag the captioning window around and resize it
Description:	NIH Director’s Wednesday Afternoon Lecture Series A screen for small-molecule modulators of the unfolded protein response yielded ISRIB, a drug-like compound that with high efficacy renders cells insensitive to translational inhibition by phosphorylation of eIF2. ISRIB is an activator of eIF2B, eIF2's guanine nucleotide exchange factor, and a cognitive enhancer in rodents, significantly improving long-term memory of wild-type animals in behavioral assays. Dr. Walter is the winner of the 2014 Lasker Award, 2014 Shaw Prize, and 2015 Vilcek Prize.

NLM Title:	From protein folding to cognition : a serendipitous path of discovery / Peter Walter.
Author:	Walter, Peter. National Institutes of Health (U.S.),
Publisher:
Abstract:	(CIT): NIH Director's Wednesday Afternoon Lecture Series. A screen for small-molecule modulators of the unfolded protein response yielded ISRIB, a drug-like compound that with high efficacy renders cells insensitive to translational inhibition by phosphorylation of eIF2. ISRIB is an activator of eIF2B, eIF2's guanine nucleotide exchange factor, and a cognitive enhancer in rodents, significantly improving long-term memory of wild-type animals in behavioral assays. Dr. Walter is the winner of the 2014 Lasker Award, 2014 Shaw Prize, and 2015 Vilcek Prize.
Subjects:	Acetamides Cognition--drug effects Cyclohexylamines
Publication Types:	Lecture Webcast

NLM Classification:	WL 337
NLM ID:	101705360
CIT Live ID:	22145
Permanent link:	https://videocast.nih.gov/watch=22145

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