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From protein folding to cognition: a serendipitous path of discovery

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Air date: Wednesday, April 19, 2017, 3:00:00 PM
Time displayed is Eastern Time, Washington DC Local
Views: Total views: 387, (118 Live, 269 On-demand)
Category: WALS - Wednesday Afternoon Lectures
Runtime: 01:02:22
Description: NIH Director’s Wednesday Afternoon Lecture Series

A screen for small-molecule modulators of the unfolded protein response yielded ISRIB, a drug-like compound that with high efficacy renders cells insensitive to translational inhibition by phosphorylation of eIF2. ISRIB is an activator of eIF2B, eIF2's guanine nucleotide exchange factor, and a cognitive enhancer in rodents, significantly improving long-term memory of wild-type animals in behavioral assays.

Dr. Walter is the winner of the 2014 Lasker Award, 2014 Shaw Prize, and 2015 Vilcek Prize.
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NLM Title: From protein folding to cognition : a serendipitous path of discovery / Peter Walter.
Author: Walter, Peter.
National Institutes of Health (U.S.),
Publisher:
Abstract: (CIT): NIH Director's Wednesday Afternoon Lecture Series. A screen for small-molecule modulators of the unfolded protein response yielded ISRIB, a drug-like compound that with high efficacy renders cells insensitive to translational inhibition by phosphorylation of eIF2. ISRIB is an activator of eIF2B, eIF2's guanine nucleotide exchange factor, and a cognitive enhancer in rodents, significantly improving long-term memory of wild-type animals in behavioral assays. Dr. Walter is the winner of the 2014 Lasker Award, 2014 Shaw Prize, and 2015 Vilcek Prize.
Subjects: Acetamides
Cognition--drug effects
Cyclohexylamines
Publication Types: Lecture
Webcast
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Caption Text: Download Caption File
NLM Classification: WL 337
NLM ID: 101705360
CIT Live ID: 22145
Permanent link: https://videocast.nih.gov/watch=22145