NIH VideoCast - Leptin and the neural circuit regulation food intake and glucose metabolism

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Leptin and the neural circuit regulation food intake and glucose metabolism

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Air date:	Wednesday, January 11, 2017, 3:00:00 PM Time displayed is Eastern Time, Washington DC Local
Views:	Total views: 465 (159 Live, 306 On-demand)
Category:	WALS - Wednesday Afternoon Lectures
Runtime:	00:57:39
Closed captioning:	Check box to display CC outside of the video Note: You can drag the captioning window around and resize it
Description:	NIH Director’s Wednesday Afternoon Lecture Series The discovery of leptin has led to the elucidation of a robust physiologic system that maintains fat stores at a relatively constant level. Leptin is a peptide hormone secreted by adipose tissue in proportion to its mass. This hormone circulates in blood and acts on the hypothalamus to regulate food intake and energy expenditure. When fat mass falls, plasma leptin levels fall stimulating appetite and suppressing energy expenditure until fat mass is restored. When fat mass increases, leptin levels increase, suppressing appetite until weight is lost. By such a mechanism, total energy stores are stably maintained within a relatively narrow range. Recessive mutations in the leptin gene are associated with massive obesity in mice and some humans. Treatment with recombinant leptin markedly reduces food intake and body weight. The low leptin levels in patients with leptin mutations are also associated with multiple abnormalities including infertility, diabetes, and immune abnormalities all of which are corrected by leptin treatment. These findings have established important links between energy stores and many other physiologic systems and led to the use of leptin as a treatment for an increasing number of other human conditions including a subset of obesity, some forms of diabetes including lipodystrophy and hypothalamic amenorrhea, the cessation of menstruation seen in extremely thin women. Identification of a physiologic system that controls energy balance establishes a biologic basis for obesity. Recent studies have explored the relationship between leptin and the reward value of food. In addition, new methods for identifying neurons activated by leptin and other stimuli have been developed as have methods for noninvasively activating cells using radio waves. These new approaches are being applied to studies of the neural processes that control feeding, a complex motivational behavior. For more information go to https://oir.nih.gov/wals

NLM Title:	Leptin and the neural circuit regulation food intake and glucose metabolism / Jeffrey Friedman.
Author:	Friedman, Jeffrey. National Institutes of Health (U.S.),
Publisher:
Abstract:	(CIT): NIH Director's Wednesday Afternoon Lecture Series The discovery of leptin has led to the elucidation of a robust physiologic system that maintains fat stores at a relatively constant level. Leptin is a peptide hormone secreted by adipose tissue in proportion to its mass. This hormone circulates in blood and acts on the hypothalamus to regulate food intake and energy expenditure. When fat mass falls, plasma leptin levels fall stimulating appetite and suppressing energy expenditure until fat mass is restored. When fat mass increases, leptin levels increase, suppressing appetite until weight is lost. By such a mechanism, total energy stores are stably maintained within a relatively narrow range. Recessive mutations in the leptin gene are associated with massive obesity in mice and some humans. Treatment with recombinant leptin markedly reduces food intake and body weight. The low leptin levels in patients with leptin mutations are also associated with multiple abnormalities including infertility, diabetes, and immune abnormalities all of which are corrected by leptin treatment. These findings have established important links between energy stores and many other physiologic systems and led to the use of leptin as a treatment for an increasing number of other human conditions including a subset of obesity, some forms of diabetes including lipodystrophy and hypothalamic amenorrhea, the cessation of menstruation seen in extremely thin women. Identification of a physiologic system that controls energy balance establishes a biologic basis for obesity. Recent studies have explored the relationship between leptin and the reward value of food. In addition, new methods for identifying neurons activated by leptin and other stimuli have been developed as have methods for noninvasively activating cells using radio waves. These new approaches are being applied to studies of the neural processes that control feeding, a complex motivational behavior.
Subjects:	Leptin--deficiency Leptin--physiology Leptin--therapeutic use Neural Pathways--physiology Obesity--prevention & control
Publication Types:	Lecture Webcast

NLM Classification:	WK 185
NLM ID:	101700290
CIT Live ID:	21591
Permanent link:	https://videocast.nih.gov/watch=21591

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