NIH VideoCast - How proteins mutated in neurodegenerative disease and cancer, PINK1 & Parkin, survey mitochondrial fidelity and respond with selective autophagy

Skip Navigation

How proteins mutated in neurodegenerative disease and cancer, PINK1 & Parkin, survey mitochondrial fidelity and respond with selective autophagy

Loading... Loading video...

225 Views

Air date:	Monday, October 17, 2016, 12:00:00 PM Time displayed is Eastern Time, Washington DC Local
Views:	Total views: 225 (30 Live, 195 On-demand)
Category:	Neuroscience
Runtime:	00:55:19
Closed captioning:	Check box to display CC outside of the video Note: You can drag the captioning window around and resize it
Description:	NIH Neuroscience Series Seminar Programmed cell death. Neurons are programmed to die in great numbers during normal human development and aberrantly die by apoptosis in several neurodegenerative disorders. Dr. Youle’s lab is exploring the molecular mechanism of apoptosis concentrating on the roles of mitochondria and the Bcl-2 family of proteins. They have found that Bcl-xL and Bax move from the cytosol compartment to the mitochondria during apoptosis and that this step critically commits cells to the death pathway. Two major aspects of this process are under investigation; the molecular trigger for Bax migration into mitochondria and the consequences of Bax insertion into mitochondria. Live cell imaging of mitochondria and Bcl-2 family members analyzed by confocal microscopy has been instrumental in recent studies that link mitochondrial division processes to Bax mediated apoptosis. Unexpectedly, Bcl-2 family proteins have been found to regulate mitochondrial morphogenesis in healthy cells leading them to actively study the roles of mitochondrial fission and fusion especially in relation to neurodegenerative diseases. Mitochondrial Quality Control. Mitochondria rapidly divide and fuse to form a dynamic network in cells. This process is essential for organelle quality control as evidenced by human neurodegenerative diseases caused by mutations in the genes of two large GTPases that mediate these processes. They have identified a series of E3 ligases on the outer mitochondrial membrane and are exploring how they control mitochondrial morphogenesis, protein turnover, and apoptosis. For more information go to https://neuroscience.nih.gov/neuroseries/Home.aspx

Author:	Richard Youle, Ph.D., Senior Investigator, Biochemistry Section, Surgical Neurology Branch, NINDS, NIH

CIT Live ID:	20100
Permanent link:	https://videocast.nih.gov/watch=20100

Related Videos...