||SACHRP provides expert advice and recommendations to the Secretary, through the Assistant Secretary for Health, on issues and topics pertaining to or associated with the protection of human research subjects. The committee is composed of 11 appointed voting members, with additional ex-officio members from Common Rule government agencies. SACHRP presently has two working subcommittees, the Subpart A Subcommittee (SAS) and the Subcommittee on Harmonization (SOH). The October 2016 meeting will include reports from both subcommittees. Topics include the following draft recommendations: Considerations for Single IRB Review, Benchmarking in Human Subjects Research, Regulatory Issues in Cluster Randomized Trials, Recommendations on OHRP and FDA draft guidance on IRB Written Procedures, and the NIH Guidelines for Research Involving Recombinant or Synthetic Nucleic Acid Molecules, Appendix M. Time is allotted on both days for public comment.